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Cells were treated with cisplatin (3, 6, 13, and 18\u2009<jats:italic>\u03bc<\/jats:italic>M) and sunitinib malate (1, 2, 4, 6, and 20\u2009<jats:italic>\u03bc<\/jats:italic>M), either in isolation or combined, over the course of 72 hours. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay, acridine orange, and monodansylcadaverine staining and flow cytometry were performed. The combination index (CI) was calculated based on the Chou and Talalay method. In isolation, cisplatin and sunitinib malate statistically (). Autophagy and apoptosis studies showed a greater incidence when the combined treatment was put into use. This hints at the possibility of a new combined therapeutic approach. If confirmed<jats:italic>in vivo<\/jats:italic>, this conjugation may provide a means of new perspectives in muscle-invasive urinary bladder cancer treatment.<\/jats:p>","DOI":"10.1155\/2013\/791406","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T21:02:12Z","timestamp":1385672532000},"page":"1-11","source":"Crossref","is-referenced-by-count":17,"title":["Synergistic Effect between Cisplatin and Sunitinib Malate on Human Urinary Bladder-Cancer Cell Lines"],"prefix":"10.1155","volume":"2013","author":[{"given":"Regina","family":"Arantes-Rodrigues","sequence":"first","affiliation":[{"name":"Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Tr\u00e1s-os-Montes and Alto Douro, Vila Real, 5001-801 Vila Real, Portugal"}]},{"given":"Ros\u00e1rio","family":"Pinto-Leite","sequence":"additional","affiliation":[{"name":"Genetic Service, Cytogenetic Laboratory, Hospital Center of Tr\u00e1s-os-Montes 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