{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:15:56Z","timestamp":1761059756615,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PIC\/IC\/82734\/2007","SFRM\/BPD\/6308\/2009"],"award-info":[{"award-number":["PIC\/IC\/82734\/2007","SFRM\/BPD\/6308\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Liga dos Amigos do Hospital de Santa Marta","award":["PIC\/IC\/82734\/2007","SFRM\/BPD\/6308\/2009"],"award-info":[{"award-number":["PIC\/IC\/82734\/2007","SFRM\/BPD\/6308\/2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>We examined the longitudinal changes of VEGF levels after percutaneous coronary intervention for predicting major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. VEGF was measured in 94 CAD patients\u2019 serum before revascularization, 1-month and 1-year after. Independently of clinical presentation, patients had lower VEGF concentration than a cohort of healthy subjects (median, IQ: 15.9, 9.0\u2013264\u2009pg\/mL versus 419, 212\u2013758\u2009pg\/mL;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) at baseline. VEGF increased to 1-month (median, IQ: 276, 167\u2013498\u2009pg\/mL;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and remained steady to 1-year (median, IQ: 320, 173\u2013497\u2009pg\/mL;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) approaching control levels. Drug eluting stent apposition and previous medication intake produced a less steep VEGF evolution after intervention (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Baseline VEGF concentration &lt;40.8\u2009pg\/mL conveyed increased risk for MACE in a 5-year follow-up. Results reflect a positive role of VEGF in recovery and support its importance in CAD prognosis.<\/jats:p>","DOI":"10.1155\/2014\/135357","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T21:00:45Z","timestamp":1404766845000},"page":"1-7","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4500-0699","authenticated-orcid":true,"given":"Catarina","family":"Ramos","sequence":"first","affiliation":[{"name":"Instituto de Bioci\u00eancias e Bioengenharia (IBB), Instituto Superior T\u00e9cnico, Universidade de Lisboa, Avenida Rovisco Pais 1, 1049-001 Lisboa, Portugal"},{"name":"Servi\u00e7o de Cardiologia, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, 1069-024 Lisboa, Portugal"}]},{"given":"Patr\u00edcia","family":"Napole\u00e3o","sequence":"additional","affiliation":[{"name":"Carlota Saldanha Lab, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"given":"Mafalda","family":"Selas","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Cardiologia, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, 1069-024 Lisboa, Portugal"}]},{"given":"Cl\u00e1udia","family":"Freixo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Cardiologia, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, 1069-024 Lisboa, Portugal"}]},{"given":"Ana Maria","family":"Viegas Crespo","sequence":"additional","affiliation":[{"name":"CESAM, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]},{"given":"Miguel","family":"Mota Carmo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Cardiologia, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, 1069-024 Lisboa, Portugal"},{"name":"CEDOC, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal"}]},{"given":"Rui","family":"Cruz Ferreira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Cardiologia, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, 1069-024 Lisboa, Portugal"},{"name":"CEDOC, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-2603","authenticated-orcid":true,"given":"Teresa","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Instituto de Bioci\u00eancias e Bioengenharia (IBB), Instituto Superior T\u00e9cnico, Universidade de Lisboa, Avenida Rovisco Pais 1, 1049-001 Lisboa, Portugal"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1038\/nature10144"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1152\/physiol.00016.2012"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1161\/01.ATV.17.11.2793"},{"issue":"6","key":"4","doi-asserted-by":"crossref","first-page":"C1375","DOI":"10.1152\/ajpcell.2001.280.6.C1375","volume":"280","year":"2001","journal-title":"American Journal of Physiology\u2014Cell Physiology"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1186\/1749-8090-8-33"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1161\/ATVBAHA.107.158014"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1242\/jcs.084301"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1161\/ATVBAHA.109.186742"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1016\/j.cell.2007.06.054"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1093\/cvr\/cvq105"},{"issue":"3","key":"11","doi-asserted-by":"crossref","first-page":"H1054","DOI":"10.1152\/ajpheart.1998.275.3.H1054","volume":"275","year":"1998","journal-title":"American Journal of Physiology. 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