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A major advantage of these nerve guides is that no foreign material remains after the device has fulfilled its task, which spares a second surgical intervention. Recently, we studied peripheral nerve regeneration using chitosan-<jats:italic>\u03b3<\/jats:italic>-glycidoxypropyltrimethoxysilane (chitosan-GPTMS) porous hybrid membranes. In our studies, these porous membranes significantly improved nerve fiber regeneration and functional recovery in rat models of axonotmetic and neurotmetic sciatic nerve injuries. In particular, the number of regenerated myelinated nerve fibers and myelin thickness were significantly higher in rat treated with chitosan porous hybrid membranes, whether or not they were used in combination with mesenchymal stem cells isolated from the Wharton\u2019s jelly of the umbilical cord. In this review, we describe our findings on the use of chitosan-GPTMS hybrids for nerve regeneration.<\/jats:p>","DOI":"10.1155\/2014\/153808","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T21:01:33Z","timestamp":1403038893000},"page":"1-7","source":"Crossref","is-referenced-by-count":15,"title":["Challenges for Nerve Repair Using Chitosan-Siloxane Hybrid Porous Scaffolds"],"prefix":"10.1155","volume":"2014","author":[{"given":"Yuki","family":"Shirosaki","sequence":"first","affiliation":[{"name":"Frontier Research Academy for Young Researchers, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, Japan"}]},{"given":"Satoshi","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan"}]},{"given":"Akiyoshi","family":"Osaka","sequence":"additional","affiliation":[{"name":"Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan"}]},{"given":"Maria A.","family":"Lopes","sequence":"additional","affiliation":[{"name":"CEMUC, Departamento de Engenharia Metal\u00fargica e Materiais, Universidade do Porto, 4200-465 Porto, Portugal"}]},{"given":"Jos\u00e9 D.","family":"Santos","sequence":"additional","affiliation":[{"name":"CEMUC, Departamento de Engenharia Metal\u00fargica e Materiais, Universidade do Porto, 4200-465 Porto, Portugal"}]},{"given":"Stefano","family":"Geuna","sequence":"additional","affiliation":[{"name":"Neuroscience Institute of the Cavalieri Ottolenghi Foundation, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy"},{"name":"Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy"}]},{"given":"Ana C.","family":"Mauricio","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal"},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias e Tecnologias Agr\u00e1rias e Agro-Alimentares (ICETA), Rua D. 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