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An enlarged set of studies were evaluated in 191 HD patients, including hematological study, lipid profile, iron metabolism, nutritional, inflammatory markers, and dialysis adequacy. The TA duplication screening in the UDP-glucuronosyltransferase 1 A1 (<jats:italic>UGT1A1<\/jats:italic>) promoter region was also performed. The<jats:italic>UGT1A1<\/jats:italic>genotype frequencies in HD patients were 49.2%, 42.4%, and 8.4% for 6\/6, 6\/7, and 7\/7 genotypes, respectively. Although no difference was found in<jats:italic>UGT1A1<\/jats:italic>genotype distribution between the three tertiles of bilirubin, significant differences were found with increasing bilirubin levels, namely, a decrease in platelet, leukocyte, and lymphocyte counts, transferrin, oxidized low-density lipoprotein (ox-LDL), ox-LDL\/low-density lipoprotein cholesterol ratio, apolipoprotein (Apo) A, Apo B, and interleukin-6 serum levels and a significant increased concentration of hemoglobin, hematocrit, erythrocyte count, iron, transferrin saturation, Apo A\/Apo B ratio, adiponectin, and paraoxonase 1 serum levels. After adjustment for age these results remained significant. Our data suggest that higher bilirubin levels are associated with beneficial effects in HD patients, by improving lipid profile and reducing the inflammatory grade, which might contribute to increase in iron availability. These results suggest a potential cardiovascular risk protection of bilirubin in HD patients.<\/jats:p>","DOI":"10.1155\/2014\/175286","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T21:00:29Z","timestamp":1410382829000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["Potential Cardiovascular Risk Protection of Bilirubin in End-Stage Renal Disease Patients under Hemodialysis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Maria do","family":"Sameiro-Faria","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Frenesius Medical Care, Nephrocare Maia, SA, Rua Altos 70, Maia, 4470-235 Porto, Portugal"}]},{"given":"Michaela","family":"Kohlova","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioqu\u00edmica, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]},{"given":"Sandra","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioqu\u00edmica, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal"}]},{"given":"Petronila","family":"Rocha-Pereira","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal"},{"name":"Centro Investiga\u00e7\u00e3o Ci\u00eancias Sa\u00fade, Universidade Beira Interior, Covilh\u00e3, Avenida Infante D. 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