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Planktonic growth assays were performed, and the inhibition of biofilm formation was evaluated. In addition, antioxidant activity was assessed by DPPH radical scavenging assay, ferrous ion chelating assay, ferric-reducing antioxidant power assay, and<jats:italic>\u03b2<\/jats:italic>-carotene bleaching assay. Toxicity was evaluated by the brine shrimp lethality test. Results showed that derriobtusone A completely inhibited the planktonic growth of<jats:italic>S. aureus<\/jats:italic>at 250 and 500\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL; however, it did not have the same activity on<jats:italic>E. coli<\/jats:italic>. Derriobtusone A reduced the biomass and colony-forming unit (cfu) of<jats:italic>S. aureus<\/jats:italic>biofilm at concentrations of 250 and 500\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. In various concentrations, it reduced the biofilm biomass of<jats:italic>E. coli<\/jats:italic>, and, in all concentrations, it weakly reduced the cfu. Derriobtusone A showed highly efficient antioxidant ability in scavenging DPPH radical and inhibiting<jats:italic>\u03b2<\/jats:italic>-carotene oxidation. The compound showed no lethality to<jats:italic>Artemia<\/jats:italic>sp. nauplii. In conclusion, derriobtusone A may be an effective molecule against<jats:italic>S. aureus<\/jats:italic>and its biofilm, as well as a potential antioxidant compound with no toxicity.<\/jats:p>","DOI":"10.1155\/2014\/248656","type":"journal-article","created":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T21:03:50Z","timestamp":1401656630000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["Antibacterial and Antioxidant Activities of Derriobtusone A Isolated from<i>Lonchocarpus obtusus<\/i>"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mayron Alves","family":"Vasconcelos","sequence":"first","affiliation":[{"name":"Laboratory of Biologically Active Molecules, Biochemistry and Molecular Biology Department, Federal University of Cear\u00e1, 60.440-970 Fortaleza, CE, Brazil"},{"name":"Institute for Biotechnology and Bioengineering (IBB), Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal"},{"name":"Integrated Laboratory of 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