{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:55:05Z","timestamp":1763535305846,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>A case of primary squamous-cell carcinoma (SCC) of the thyroid which had been initially diagnosed as an anaplastic carcinoma (ATC) is described: female, 73 years old, with a fast-growing cervical nodule on the left side and hoarseness for 3 months. Ultrasonography showed a 4.5\u2009cm solid nodule. FNA was compatible with poorly differentiated carcinoma with immunoreactivity for AE1\/AE3, EMA. Thyroidectomy was performed. Histopathological examination showed a nonencapsulated tumor. Immunohistochemistry disclosed positivity for AE1\/AE3, p53,p63, and Ki67. The diagnosis was ATC. A second opinion reported tumor consisting of squamous cells, with intense inflammatory infiltrate both in tumor and in the adjacent thyroid, with final diagnosis of SCC, associated with Hashimoto thyroiditis. No other primary focus of SCC was found. Patient has shown a 48-month survival period. Clinically, primary SCCs of the thyroid and ATCs are similar. The distinction is often difficult particularly when based on the cytological analysis of FNA material.<\/jats:p>","DOI":"10.1155\/2014\/301780","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T17:00:43Z","timestamp":1410282043000},"page":"1-4","source":"Crossref","is-referenced-by-count":9,"title":["Primary Squamous Cell Carcinoma of the Thyroid Diagnosed as Anaplastic Carcinoma: Failure in Fine-Needle Aspiration Cytology?"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-592X","authenticated-orcid":true,"given":"Fernanda","family":"Bolfi","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Internal Medicine Department, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil"}]},{"given":"Maria A. C.","family":"Domingues","sequence":"additional","affiliation":[{"name":"Pathology Department, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil"}]},{"given":"Manuel","family":"Sobrinho-Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-6998","authenticated-orcid":true,"given":"Paula","family":"Soares","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9605-6433","authenticated-orcid":true,"given":"Ricardo","family":"Celestino","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal"}]},{"given":"Emanuel C.","family":"Castilho","sequence":"additional","affiliation":[{"name":"Head and Neck Department, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil"}]},{"given":"Guareide","family":"Carelli","sequence":"additional","affiliation":[{"name":"Division of Clinical Oncology, Internal Medicine Department, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil"}]},{"given":"Norberto S.","family":"Paes","sequence":"additional","affiliation":[{"name":"Division of Radiotherapy, Department of Dermatology and Radiotherapy, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil"}]},{"given":"Glaucia M. 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