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The most common abnormality is iris hypoplasia; however, a panocular disease which also affects the cornea, anterior chamber of the eye, lens, and the posterior segment with presence of optic nerve and foveal hypoplasia is also evident. The development of keratopathy, glaucoma, and cataract is frequent and its presence has implications in the patient\u2019s visual acuity. Managing aniridia is challenging since the focus is on treating the previously mentioned disorders, and the outcomes are often disappointing. In this paper, we shall review the epidemiology, pathophysiology, and clinical characteristics of patients with aniridia. We shall also make a review of the therapeutic options for the several conditions affecting this syndrome and consider the genetics and prognostic factors.<\/jats:p>","DOI":"10.1155\/2014\/305350","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T21:02:29Z","timestamp":1414702949000},"page":"1-10","source":"Crossref","is-referenced-by-count":13,"title":["Congenital Aniridia: Clinic, Genetics, Therapeutics, and Prognosis"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-2317","authenticated-orcid":true,"given":"Pedro","family":"Calv\u00e3o-Pires","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Porto, Hospital de S\u00e3o Jo\u00e3o, Alameda Professor Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"R.","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Faculty of Medicine, University of Porto, Hospital de S\u00e3o 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