{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T05:46:37Z","timestamp":1759383997361},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Surgery"],"published-print":{"date-parts":[[2014,3,4]]},"abstract":"<jats:p><jats:italic>Goal<\/jats:italic>. To evaluate the prognostic value of Mandard and Dworak grading systems regarding neoadjuvant chemoradiotherapy (CRT) response on rectal cancer. \n<jats:italic>Materials and Methods<\/jats:italic>. We queried our center\u2019s database for patients with colo rectal cancer with locally advanced rectal cancer (LARC) who received neoadjuvant CRT followed by total mesorectum excision (TME) between 2003 and 2011. After excluding 18 patients from the initial query the remaining 139 were reassessed for disease recurrence and survival; the specimens\u2019 slides were reviewed and classified according to two tumor regression grading (TRG) systems: Mandard and Dworak. Based on these TRG scores, two patient groups were created: patients with good response versus patients with bad response (Mandard TRG1+2 versus Mandard TRG3+4+5 and Dworak TRG4+3 versus Dworak TRG2+1+0). Overall survival (OS), disease-free survival (DFS), and disease recurrence were then evaluated. <jats:italic>Results<\/jats:italic>. Mean age was 64.2 years and median follow up was 56 months. No  significant survival difference was found when comparing patients with Dworak TRG 4+3 versus Dworak TRG2+1+0 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>0.<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:math>). Mandard TRG1+2 presented with significantly better OS and DFS than Mandard TRG3+4+5 (OS <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>0.<\/mml:mo><mml:mn>013<\/mml:mn><\/mml:math>; DFS <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>0.<\/mml:mo><mml:mn>007<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. Mandard system provides higher accuracy over Dworak system in predicting rectal cancer prognosis when neoadjuvant CRT is applied for tumor regression.<\/jats:p>","DOI":"10.1155\/2014\/310542","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T21:06:18Z","timestamp":1393967178000},"page":"1-8","source":"Crossref","is-referenced-by-count":29,"title":["Prognostic Value of Mandard and Dworak Tumor Regression Grading in Rectal Cancer: Study of a Single Tertiary Center"],"prefix":"10.1155","volume":"2014","author":[{"given":"Marisa D.","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Surgery, Digestive Surgery Service, Hospital de Santo Ant\u00f3nio, Largo Professor Abel Salazar, 4099-003 Porto, Portugal"}]},{"given":"Cristina","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Surgery, Digestive Surgery Service, Hospital de Santo Ant\u00f3nio, Largo Professor Abel Salazar, 4099-003 Porto, Portugal"}]},{"given":"Anabela","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Surgery, Digestive Surgery Service, Hospital de Santo Ant\u00f3nio, Largo Professor Abel Salazar, 4099-003 Porto, Portugal"}]},{"given":"Eduarda","family":"Matos","sequence":"additional","affiliation":[{"name":"Department of Community Health, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Rua Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal"}]},{"given":"Carlos","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Surgery, Digestive Surgery Service, Hospital de Santo Ant\u00f3nio, Largo Professor Abel Salazar, 4099-003 Porto, Portugal"}]},{"given":"Carlos","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pathological Anatomy Service, Hospital de Santo Ant\u00f3nio, Largo Professor Abel Salazar, 4099-003 Porto, Portugal"},{"name":"Department of Pathology and Molecular Immunology, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Rua Jorge Viterbo Ferreira No. 228, 4050-313 Porto, 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