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Five-week old rats were exposed to crowding for two weeks. Crowding elevated plasma corticosterone<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>and accelerated BP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>versus basal) only in BHR. NO production and superoxide concentration were significantly higher in the aortas of control BHR and SHR versus WKY. Total acetylcholine (ACh)-induced relaxation in the femoral artery was reduced in control SHR versus WKY and BHR, and stress did not affect it significantly in any genotype. The attenuation of ACh-induced relaxation in SHR versus WKY was associated with reduction of its NO-independent component. Crowding elevated NO production in all strains investigated but superoxide concentration was increased only in WKY, which resulted in reduced NO-dependent relaxation in WKY. In crowded BHR and SHR, superoxide concentration was either unchanged or reduced, respectively, but NO-dependent relaxation was unchanged in both BHR and SHR versus their respective control group. This study points to genotype-related differences in stress vulnerability in young female rats. The most pronounced negative influence of stress was observed in BHR despite preserved endothelial function.<\/jats:p>","DOI":"10.1155\/2014\/413629","type":"journal-article","created":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T05:21:03Z","timestamp":1394342463000},"page":"1-11","source":"Crossref","is-referenced-by-count":19,"title":["Genotype-Related Effect of Crowding Stress on Blood Pressure and Vascular Function in Young Female Rats"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9757-3283","authenticated-orcid":true,"given":"Peter","family":"Slezak","sequence":"first","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Centre of Excellence for Examination of Regulatory Role of Nitric Oxide in Civilization Diseases, Slovak Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovakia"}]},{"given":"Angelika","family":"Puzserova","sequence":"additional","affiliation":[{"name":"Institute of Normal and 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