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Whether this microglia-mediated neuroinflammation is cause or consequence of neurodegeneration is still a matter of controversy. However, it is unequivocal that chronic neuroinflammation plays a role in disease progression and halting that process represents a potential therapeutic strategy. The neuromodulator adenosine emerges as a promising targeting candidate based on its ability to regulate microglial proliferation, chemotaxis, and reactivity through the activation of its G protein coupled<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mtext>A<\/mml:mtext><mml:mrow><mml:mtext>2A<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>receptor (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msub><mml:mrow><mml:mtext>A<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">2<\/mml:mn><mml:mtext>A<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mtext>R<\/mml:mtext><\/mml:math>). This is in striking agreement with the ability of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:msub><mml:mrow><mml:mtext>A<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">2<\/mml:mn><mml:mtext>A<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mtext>R<\/mml:mtext><\/mml:math>blockade to control several brain diseases. Retinal degenerative diseases have been also associated with microglia-mediated neuroinflammation, but the role of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:msub><mml:mrow><mml:mtext>A<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">2<\/mml:mn><mml:mtext>A<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mtext>R<\/mml:mtext><\/mml:math>has been scarcely explored. This review aims to compare inflammatory features of Parkinson\u2019s and Alzheimer\u2019s diseases with glaucoma and diabetic retinopathy, discussing the therapeutic potential of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:msub><mml:mrow><mml:mtext>A<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">2<\/mml:mn><mml:mtext>A<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mtext>R<\/mml:mtext><\/mml:math>in these degenerative conditions.<\/jats:p>","DOI":"10.1155\/2014\/465694","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T22:05:40Z","timestamp":1405548340000},"page":"1-13","source":"Crossref","is-referenced-by-count":68,"title":["Role of Microglia Adenosine A<sub>2A<\/sub>Receptors in Retinal and Brain Neurodegenerative Diseases"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ana R.","family":"Santiago","sequence":"first","affiliation":[{"name":"Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"AIBILI, 3000-548 Coimbra, Portugal"},{"name":"Center for Neuroscience and Cell Biology, Largo Marqu\u00eas de Pombal, Universidade de Coimbra, 3004-517 Coimbra, Portugal"},{"name":"Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal"}]},{"given":"Filipa I.","family":"Baptista","sequence":"additional","affiliation":[{"name":"Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Paulo F.","family":"Santos","sequence":"additional","affiliation":[{"name":"Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Neuroscience and Cell Biology, Largo Marqu\u00eas de Pombal, Universidade de Coimbra, 3004-517 Coimbra, Portugal"},{"name":"Department of Life Sciences, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"given":"Gon\u00e7alo","family":"Crist\u00f3v\u00e3o","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology, Largo Marqu\u00eas de Pombal, Universidade de Coimbra, 3004-517 Coimbra, Portugal"}]},{"given":"Ant\u00f3nio F.","family":"Ambr\u00f3sio","sequence":"additional","affiliation":[{"name":"Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"AIBILI, 3000-548 Coimbra, Portugal"},{"name":"Center for Neuroscience and Cell Biology, Largo Marqu\u00eas de Pombal, Universidade de Coimbra, 3004-517 Coimbra, Portugal"},{"name":"Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal"}]},{"given":"Rodrigo A.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology, Largo Marqu\u00eas de Pombal, Universidade de Coimbra, 3004-517 Coimbra, 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