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Nonetheless, little is known about the contribution of these newly microbes to the resilience of CF-associated biofilms, particularly under variable-oxygen concentrations that are known to occur<jats:italic>in vivo<\/jats:italic>in the mucus of CF patients. Two CF-emergent bacterial species,<jats:italic>Inquilinus limosus<\/jats:italic>and<jats:italic>Dolosigranulum pigrum<\/jats:italic>, and the major pathogen<jats:italic>Pseudomonas aeruginosa<\/jats:italic>were studied in terms of biofilm development and antibiotic susceptibilities under<jats:italic>in vitro<\/jats:italic>atmospheres with different oxygen availabilities. All species were able to develop<jats:italic>in vitro<\/jats:italic>biofilms under different oxygen-available environments, with<jats:italic>D. pigrum<\/jats:italic>accumulating high amounts of biomass and respiratory activities. When established, biofilms were of difficult eradication, with antibiotics losing their effectiveness in comparison with the corresponding planktonic populations. Surprisingly, biofilms of each emergent organism displayed multidrug resistance under aerobic environments, enduring even in low-oxygen atmospheres. This study suggests a potential prospect on the impact of nonconventional organisms<jats:italic>I. limosus<\/jats:italic>and<jats:italic>D. pigrum<\/jats:italic>on CF lung infections, demonstrating capacity to adapt to biofilm mode of life under restricted-oxygen atmospheres resembling CF airways, which may ultimately endanger the efficacy of currently used antibiotic regimens.<\/jats:p>","DOI":"10.1155\/2014\/678301","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T21:09:29Z","timestamp":1398805769000},"page":"1-7","source":"Crossref","is-referenced-by-count":26,"title":["Emergent Bacteria in Cystic Fibrosis:<i>In Vitro<\/i>Biofilm Formation and Resilience under Variable Oxygen Conditions"],"prefix":"10.1155","volume":"2014","author":[{"given":"Susana P.","family":"Lopes","sequence":"first","affiliation":[{"name":"Institute for Biotechnology and Bioengineering (IBB), Centre for Biological Engineering, Universidade do Minho, Campus de Gualtar, 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