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In this study, the effects of bleeding followed by replacement with hydroxyethyl starch 130\/0.4 (HES) or lactated Ringer\u2019s (LR) on cerebral oxygenation and electroencephalogram-derived parameters were investigated. Twelve young pigs under propofol-remifentanil anaesthesia were bled 30\u2009mL\/kg and, after a 20-minute waiting period, volume replacement was performed with HES (G<jats:sub>HES<\/jats:sub>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:math>) or LR (G<jats:sub>RL<\/jats:sub>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:math>). Bleeding caused a decrease of more than 50% in mean arterial pressure (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) and a decrease in cerebral oximetry (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.039<\/mml:mn><\/mml:math>), bispectral index, and electroencephalogram total power (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>, resp.), while propofol plasma concentrations increased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). Both solutions restored the haemodynamics and cerebral oxygenation similarly and were accompanied by an increase in electroencephalogram total power. No differences between groups were found. However, one hour after the end of the volume replacement, the cardiac output (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.03<\/mml:mn><\/mml:math>) and the cerebral oxygenation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:math>) decreased in the G<jats:sub>LR<\/jats:sub>and were significantly lower than in G<jats:sub>HES<\/jats:sub>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>). Volume replacement with HES 130\/0.4 was capable of maintaining the cardiac output and cerebral oxygenation during a longer period than LR and caused a decrease in the propofol plasma concentrations.<\/jats:p>","DOI":"10.1155\/2014\/710394","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T21:22:11Z","timestamp":1400534531000},"page":"1-12","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130\/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs"],"prefix":"10.4061","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-6320","authenticated-orcid":true,"given":"Aura","family":"Silva","sequence":"first","affiliation":[{"name":"Toxicology Department, REQUIMTE, Faculdade de Farmacia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6317-9237","authenticated-orcid":true,"given":"Ana Liza","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Universidad de Leon, Avenida Facultad de Veterinaria, No. 25, 24004 Le\u00f3n, Spain"}]},{"given":"Carlos","family":"Ven\u00e2ncio","sequence":"additional","affiliation":[{"name":"Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Animal Science Department, University of Tras-os-Montes and Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"}]},{"given":"Almir P.","family":"Souza","sequence":"additional","affiliation":[{"name":"Unidade Academica de Medicina Veterin\u00e1ria, Universidade Federal de Campina Grande, Patos, Rua Sinfr\u00f4nio Nazar\u00e9, 1 Centro, 58800-240 Sousa, PB, Brazil"}]},{"given":"Lu\u00edsa Maria","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, EQUIMTE\/CBQF, Quinta da Torre, 2829-516 Caparica, Portugal"}]},{"given":"Paula S\u00e9rio","family":"Branco","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, EQUIMTE\/CBQF, Quinta da Torre, 2829-516 Caparica, Portugal"}]},{"given":"Paula Guedes","family":"de Pinho","sequence":"additional","affiliation":[{"name":"Toxicology Department, REQUIMTE, Faculdade de Farmacia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal"}]},{"given":"Pedro","family":"Amorim","sequence":"additional","affiliation":[{"name":"Anaesthesiology Department, Hospital Geral de Santo Antonio, 4099-001 Porto, Portugal"}]},{"given":"David A.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Veterinary Sciences Research Center (CICV), Faculdade de Medicina Veterinaria, Universidade Lus\u00f3fona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, 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