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Energy expenditure has been negatively correlated with fat accumulation. However, this association is highly variable. In the present study we applied a genotype by environment interaction method to examine the presence of Genotype x by Total Daily Energy Expenditure and Genotype x by Daily Energy Expenditure interactions in the expression of different body composition traits.<jats:italic>Methods and Results<\/jats:italic>. A total of 958 subjects from 294 families of<jats:italic>The Portuguese Healthy Family Study<\/jats:italic>were included in the analysis. TDEE and DEE were assessed using a physical activity recall. Body fat percentages were measured with a bioelectrical impedance scale. GxTDEE and GxDEE examinations were performed using SOLAR 4.0 software. All BC traits were significantly heritable, with heritabilities ranging from 21% to 34%. The GxTDEE and GxDEE interaction models fitted the data better than the polygenic model for all traits. For all traits, a significant GxTDEE and GxDEE interaction was due to variance heterogeneity among distinct levels of TDEE and DEE. For WC, GxTDEE was also significant due to the genetic correlation function.<jats:italic>Conclusions<\/jats:italic>. TDEE and DEE are environmental constraints associated with the expression of individuals\u2019 BC genotypes, leading to variability in the phenotypic expression of BC traits.<\/jats:p>","DOI":"10.1155\/2014\/845207","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T03:17:25Z","timestamp":1395803845000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["Genotype by Energy Expenditure Interaction and Body Composition Traits: The Portuguese Healthy Family Study"],"prefix":"10.1155","volume":"2014","author":[{"given":"D. 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