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Recently,<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>data suggest that propolis has anticancer properties, but is the cytoxicity of propolis specific for tumor cells? To answer this question, the cytotoxicity of phenolic extracts from Portuguese propolis of different origins was evaluated using human tumor cell lines (MCF7\u2014breast adenocarcinoma, NCI-H460\u2014non-small cell lung carcinoma, HCT15\u2014colon carcinoma, HeLa\u2014cervical carcinoma, and HepG2\u2014hepatocellular carcinoma), and non-tumor primary cells (PLP2). The studied propolis presented high cytotoxic potential for human tumor cell lines, mostly for HCT15. Nevertheless, excluding HCT15 cell line, the extracts at the GI<jats:sub>50<\/jats:sub>obtained for tumor cell lines showed, in general, cytotoxicity for normal cells (PLP2). Propolis phenolic extracts comprise phytochemicals that should be further studied for their bioactive properties against human colon carcinoma. In the other cases, the proximity of the<jats:italic>in vitro<\/jats:italic>cytotoxic doses for tumor and normal cell lines should be confirmed by<jats:italic>in vivo<\/jats:italic>tests and may highlight the need for selection of specific compounds within the propolis extract.<\/jats:p>","DOI":"10.1155\/2014\/897361","type":"journal-article","created":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T17:14:05Z","timestamp":1401642845000},"page":"1-7","source":"Crossref","is-referenced-by-count":33,"title":["Cytotoxicity of Portuguese Propolis: The Proximity of the<i>In Vitro<\/i>Doses for Tumor and Normal Cell Lines"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-4578","authenticated-orcid":true,"given":"Ricardo C.","family":"Calhelha","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), ESA, Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Apartado 1172, 5301-855 Bragan\u00e7a, Portugal"},{"name":"Centro de Qu\u00edmica, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Soraia","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), ESA, Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Apartado 1172, 5301-855 Bragan\u00e7a, Portugal"}]},{"given":"Maria Jo\u00e3o R. P.","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-5280","authenticated-orcid":true,"given":"Miguel","family":"Vilas-Boas","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), ESA, Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Apartado 1172, 5301-855 Bragan\u00e7a, Portugal"}]},{"given":"Isabel C. F. 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