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We examined EMMPRIN and Ki-67 proteins expression by immunohistochemistry in 74 cases with OSCC. Statistical analysis was conducted to examine their clinicopathological and prognostic significance in OSCC. EMMPRIN membrane expression was observed in all cases, with both membrane and cytoplasmic tumor expression in 61 cases (82.4%). EMMPRIN overexpression was observed in 56 cases (75.7%). Moderately or poorly differentiated tumors showed EMMPRIN overexpression more frequently than well-differentiated tumors<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. Overexpression of EMMPRIN was correlated with high Ki-67 expression<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. In the multivariate analysis, EMMPRIN overexpression reveals an adverse independent prognostic value for cancer-specific survival (CSS)<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.034<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. Our results reveal that EMMPRIN protein is overexpressed in more than two-thirds of OSCC cases, especially in high proliferative and less differentiated tumors. The independent value of EMMPRIN overexpression in CSS suggests that this protein could be used as an important biological prognostic marker for patients with OSCC. Moreover, the high expression of EMMPRIN makes it a possible therapeutic target in OSCC patients.<\/jats:p>","DOI":"10.1155\/2014\/905680","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T17:13:21Z","timestamp":1400692401000},"page":"1-9","source":"Crossref","is-referenced-by-count":32,"title":["EMMPRIN Expression in Oral Squamous Cell Carcinomas: Correlation with Tumor Proliferation and Patient Survival"],"prefix":"10.1155","volume":"2014","author":[{"given":"Lu\u00eds Silva","family":"Monteiro","sequence":"first","affiliation":[{"name":"Molecular Oncology Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Higher Institute of Health Sciences, CESPU, 4585-116 Paredes, Portugal"},{"name":"Medicine and Oral Surgery Department, Higher Institute of Health Sciences, 4585-116 Paredes, Portugal"}]},{"given":"Maria Leonor","family":"Delgado","sequence":"additional","affiliation":[{"name":"Molecular Oncology Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Higher Institute of Health Sciences, CESPU, 4585-116 Paredes, Portugal"}]},{"given":"Sara","family":"Ricardo","sequence":"additional","affiliation":[{"name":"Pathology Department, Higher School of Health of Vale do Sousa, 4585-116 Paredes, Portugal"},{"name":"Differentiation and Cancer Group, Institute of Molecular Pathology and Immunology of the University of Porto, (IPATIMUP), 4200-465 Porto, Portugal"}]},{"given":"Fernanda","family":"Garcez","sequence":"additional","affiliation":[{"name":"Pathology Department, Higher School of Health of Vale do Sousa, 4585-116 Paredes, Portugal"}]},{"given":"Barbas do","family":"Amaral","sequence":"additional","affiliation":[{"name":"Molecular Oncology Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Higher Institute of Health Sciences, CESPU, 4585-116 Paredes, Portugal"},{"name":"Medicine and Oral Surgery Department, Higher Institute of Health Sciences, 4585-116 Paredes, Portugal"},{"name":"Stomatology Department, Santo Ant\u00f3nio Hospital, Oporto Hospitalar Centre, 4099-001 Porto, Portugal"}]},{"given":"Jos\u00e9 J\u00falio","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Molecular Oncology Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Higher Institute of Health Sciences, CESPU, 4585-116 Paredes, Portugal"},{"name":"Medicine and Oral Surgery Department, Higher Institute of Health Sciences, 4585-116 Paredes, Portugal"}]},{"given":"Carlos","family":"Lopes","sequence":"additional","affiliation":[{"name":"Molecular Pathology and Immunology Department, Institute of Biomedical Sciences Abel Salazar (ICBAS), Porto University, 4050-313 Porto, 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