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In spite of a high number of clinical trials no other drug has proved effectiveness. Recent studies support that vascular endothelial growth factor (VEGF), originally described as a key angiogenic factor, also plays a key role in the nervous system, including neurogenesis, neuronal survival, neuronal migration, and axon guidance. VEGF has been used in exploratory clinical studies with promising results in ALS and other neurological disorders. Although VEGF is a very promising compound, translating the basic science breakthroughs into clinical practice is the major challenge ahead. VEGF-B, presenting a single safety profile, protects motor neurons from degeneration in ALS animal models and, therefore, it will be particularly interesting to test its effects in ALS patients. In the present paper the authors make a brief description of the molecular properties of VEGF and its receptors and review its different features and therapeutic potential in the nervous system\/neurodegenerative disease, particularly in ALS.<\/jats:p>","DOI":"10.1155\/2014\/947513","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T21:11:56Z","timestamp":1398805916000},"page":"1-24","source":"Crossref","is-referenced-by-count":41,"title":["Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ana Catarina","family":"Pronto-Laborinho","sequence":"first","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine, University of Lisbon, Avenida Professor Egas Moniz, 1649-028 Lisbon, Portugal"},{"name":"Instituto de Medicina Molecular (IMM), Translational Clinical Physiology Unit, Avenida Professor Egas Moniz, 1649-028 Lisbon, 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