{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:02:41Z","timestamp":1761102161916,"version":"3.41.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015661","name":"UCB Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015661","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To compare the effectiveness of TNF inhibitors (TNFi) and tocilizumab in rheumatoid arthritis (RA) treatment, according to different response criteria.<jats:italic>Methods<\/jats:italic>. We included RA patients registered in the Rheumatic Diseases Portuguese Register treated with TNFi or tocilizumab for at least 6 months, between January 2008 and July 2013. We assessed remission\/low disease activity (LDA) at 6 months according to DAS28, CDAI, and SDAI, as well as Boolean ACR\/EULAR remission and EULAR response rate, adjusting for measured confounders.<jats:italic>Results<\/jats:italic>. Tocilizumab-treated patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>95<\/mml:mn><\/mml:mrow><\/mml:math>) presented higher baseline disease activity and were less frequently na\u00efve to biologics compared to TNFi users (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>429<\/mml:mn><\/mml:mrow><\/mml:math>). Multivariate logistic regression analysis including the propensity score for receiving tocilizumab showed that patients treated with tocilizumab were more likely to achieve remission or LDA according to DAS28 (OR = 11.0\/6.2, 95% CI 5.6\u201321.6\/3.2\u201312.0), CDAI (OR = 2.8\/2.6, 95% CI 1.2\u20136.5\/1.3\u20135.5), or SDAI (OR = 3.6\/2.5, 95% CI 1.5\u20138.7\/1.1\u20135.5), as well as a good EULAR response (OR = 6.4, 95% CI 3.4\u201312.0). However, both groups did not differ in Boolean remission (OR = 1.9, 95% CI 0.8\u20134.8) or good\/moderate EULAR response (OR = 1.8, 95% CI 0.8\u20134.5).<jats:italic>Conclusions<\/jats:italic>. Compared with TNFi, tocilizumab was associated with greater likelihood of achieving DAS28, CDAI, and SDAI remission\/LDA and EULAR good response. Boolean remission and EULAR good\/moderate response did not differ significantly between groups.<\/jats:p>","DOI":"10.1155\/2015\/279890","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T21:02:53Z","timestamp":1430168573000},"page":"1-13","source":"Crossref","is-referenced-by-count":16,"title":["Comparative Effectiveness of Tocilizumab and TNF Inhibitors in Rheumatoid Arthritis Patients: Data from the Rheumatic Diseases Portuguese Register, Reuma.pt"],"prefix":"10.1155","volume":"2015","author":[{"given":"Vasco","family":"C. Rom\u00e3o","sequence":"first","affiliation":[{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon Academic Medical Centre, Edif\u00edcio Egas Moniz, Avenida Prof. Egas Moniz, 1649-028 Lisboa, Portugal"},{"name":"Rheumatology Department, Hospital de Santa Maria, Lisbon Academic Medical Centre, Avenida Prof. Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"given":"Maria Jos\u00e9","family":"Santos","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital de Santa Maria, Lisbon Academic Medical Centre, Avenida Prof. Egas Moniz, 1649-028 Lisboa, Portugal"},{"name":"Rheumatology Department, Hospital Garcia de Orta, Avenida Prof. Torrado da Silva, 2801-951 Almada, Portugal"}]},{"given":"Joaquim","family":"Polido-Pereira","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon Academic Medical Centre, Edif\u00edcio Egas Moniz, Avenida Prof. Egas Moniz, 1649-028 Lisboa, Portugal"},{"name":"Rheumatology Department, Hospital de Santa Maria, Lisbon Academic Medical Centre, Avenida Prof. Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"given":"C\u00e1tia","family":"Duarte","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar Universit\u00e1rio de Coimbra, Praceta Mota Pinto, 3000-076 Coimbra, Portugal"}]},{"given":"Patr\u00edcia","family":"Nero","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Rua da Junqueira 126, 1349-019 Lisboa, Portugal"}]},{"given":"Cl\u00e1udia","family":"Miguel","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Instituto Portugu\u00eas de Reumatologia, R. Benefic\u00eancia 7, 1050-034 Lisboa, Portugal"}]},{"given":"Jos\u00e9 Ant\u00f3nio","family":"Costa","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Unidade Local de Sa\u00fade do Alto Minho, Hospital Conde de Bertiandos, Largo Conde de Bertiandos, 4990-041 Ponte de Lima, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-5465","authenticated-orcid":true,"given":"Miguel","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Fernando M.","family":"Pimentel-Santos","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Rua da Junqueira 126, 1349-019 Lisboa, Portugal"},{"name":"CEDOC, NOVA Medical School, Nova University, Campo dos M\u00e1rtires da P\u00e1tria 130, 1169-056 Lisboa, Portugal"}]},{"given":"Filipe","family":"Barcelos","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Instituto Portugu\u00eas de Reumatologia, R. Benefic\u00eancia 7, 1050-034 Lisboa, Portugal"}]},{"given":"L\u00facia","family":"Costa","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Jos\u00e9 Ant\u00f3nio","family":"Melo Gomes","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Instituto Portugu\u00eas de Reumatologia, R. 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