{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:46:48Z","timestamp":1770842808007,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100011733","name":"Portuguese League against Cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011733","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>We aimed to characterize miR-125b and miR-34a expression in 114 women with different cervical lesions: normal epithelium with (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><\/mml:mrow><\/mml:math>= 20) and without (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><\/mml:mrow><\/mml:math>= 29) HPV infection; LSIL (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>n<\/mml:mi><\/mml:mrow><\/mml:math>= 28); HSIL (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>n<\/mml:mi><\/mml:mrow><\/mml:math>= 29); and ICC (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>n<\/mml:mi><\/mml:mrow><\/mml:math>= 8). miRNA expression analysis was performed by comparing the distinct groups with the reference group (women with normal epithelium without HPV). For miR-125b, we observed a twofold (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:msup><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><mml:mi>\u0394<\/mml:mi><mml:mi>\u0394<\/mml:mi><mml:mtext>Ct<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>= 2.11;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>= 0.038) increased expression among women with normal epithelium with HPV infection and a trend of downregulation in different cervical lesions including an 80% reduction (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:msup><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><mml:mi>\u0394<\/mml:mi><mml:mi>\u0394<\/mml:mi><mml:mtext>Ct<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>= 0.21;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>= 0.004) in ICC. Similarly, miR-34a expression analysis revealed an increased expression (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mrow><mml:msup><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><mml:mi>\u0394<\/mml:mi><mml:mi>\u0394<\/mml:mi><mml:mtext>Ct<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>= 1.69;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>= 0.049) among women with normal cervix and HPV infection, and despite no significant correlation with cervical lesions, its expression was increased by twofold (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mrow><mml:msup><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><mml:mi>\u0394<\/mml:mi><mml:mi>\u0394<\/mml:mi><mml:mtext>Ct<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>= 2.08;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>= 0.042) in ICC. Moreover, miR-125b levels were able to predict invasive cancers with 88% sensitivity and 69% specificity. Results showed that while miR-34a expression seems to be correlated with invasive cervical cancer, miR-125b expression is significantly changed within the different cervical lesions and their levels should be further investigated as possible predictive\/prognostic biomarkers using a noninvasive approach.<\/jats:p>","DOI":"10.1155\/2015\/304584","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T07:41:24Z","timestamp":1434008484000},"page":"1-6","source":"Crossref","is-referenced-by-count":49,"title":["miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8431-9718","authenticated-orcid":true,"given":"Joana","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Virology Service, Portuguese Institute of Oncology of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-072 Porto, Portugal"},{"name":"Molecular Oncology and Viral 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