{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:13:47Z","timestamp":1740161627952,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004049","name":"Katholischer Akademischer Ausl\u00e4nder-Dienst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research and Treatment"],"published-print":{"date-parts":[[2015,11,30]]},"abstract":"<jats:p>In chronic lymphocytic leukemia (CLL), presence of acquired cytogenetic abnormalities may help to estimate prognosis. However, deletion of<jats:italic> TP53<\/jats:italic> gene, which is associated with an aggressive course of the disease and poor prognosis along with a lack of response to treatment, is one of the alterations which may escape cytogenetic diagnoses in CLL. Thus, other techniques have emerged such as interphase fluorescence<jats:italic> in situ<\/jats:italic> hybridization (iFISH). Deletion of<jats:italic> TP53<\/jats:italic> may but must not go together with the formation of an isochromosome i(17q); surprisingly this subgroup of patients was not in the focus of CLL studies yet. This study was about if presence of i(17q) could be indicative for a new subgroup in CLL with more adverse prognosis. As a result,<jats:italic> TP53<\/jats:italic> deletion was detected in 18 out of 150 (12%) here studied CLL cases. Six of those cases (~33%) had the<jats:italic> TP53<\/jats:italic> deletion accompanied by an i(17q). Interestingly, the cases with i(17q) showed a tendency towards more associated chromosomal aberrations. These findings may be the bases for follow-up studies in CLL patients with<jats:italic> TP53<\/jats:italic> deletion with and without i(17q); it may be suggested that the i(17q) presents an even more adverse prognostic marker than<jats:italic> TP53<\/jats:italic> deletion alone.<\/jats:p>","DOI":"10.1155\/2015\/489592","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T21:43:32Z","timestamp":1448919812000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Isochromosome 17q in Chronic Lymphocytic Leukemia"],"prefix":"10.1155","volume":"2015","author":[{"given":"Eyad","family":"Alhourani","sequence":"first","affiliation":[{"name":"Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Kollegiengasse 10, 07743 Jena, Germany"}]},{"given":"Martina","family":"Rincic","sequence":"additional","affiliation":[{"name":"Croatian Institute of Brain Research, Salata 12, 1000 Zagreb, Croatia"}]},{"given":"Joana 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