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The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between<jats:italic>PTPRC<\/jats:italic>locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response.<jats:italic>Methods<\/jats:italic>. We evaluated associations between anti-TNF treatment responses assessed by DAS28 change and by EULAR response at six months in 383 Portuguese patients. Univariate and multivariate linear and logistic regression analyses were performed. In a second step to confirm our findings, we pooled our population with 265 Spanish patients.<jats:italic>Results<\/jats:italic>. No association was found between<jats:italic>PTPRC<\/jats:italic>rs10919563 allele and anti-TNF treatment response, neither in Portuguese modeling for several clinical variables nor in the overall population combining Portuguese and Spanish patients. The minor allele for RA susceptibility, rs3761847 SNP in<jats:italic>TRAF1\/C5<\/jats:italic>region, was associated with a poor response in linear and logistic univariate and multivariate regression analyses. No association was observed with the other allellic variants. Results were confirmed in the pooled analysis.<jats:italic>Conclusion<\/jats:italic>. This study did not replicate the association between<jats:italic>PTPRC<\/jats:italic>and the response to anti-TNF treatment in our Southern European population. We found that<jats:italic>TRAF1\/C5<\/jats:italic>risk RA variants potentially influence anti-TNF treatment response.<\/jats:p>","DOI":"10.1155\/2015\/490295","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T21:02:17Z","timestamp":1425589337000},"page":"1-9","source":"Crossref","is-referenced-by-count":19,"title":["<i>TRAF1\/C5<\/i>but Not<i>PTPRC<\/i>Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-4870","authenticated-orcid":true,"given":"Helena","family":"Canh\u00e3o","sequence":"first","affiliation":[{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, Edif\u00edcio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Avenida Egas Moniz, 1649-028 Lisbon, Portugal"},{"name":"Rheumatology Department, Hospital de Santa Maria (CHLN), Lisbon Academic Medical Centre, 1649-035 Lisbon, Portugal"},{"name":"Division of Rheumatology, Allergy and Immunology, Section of Clinical Sciences, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"}]},{"given":"Ana Maria","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, Edif\u00edcio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Avenida Egas Moniz, 1649-028 Lisbon, Portugal"},{"name":"Rheumatology Department, Hospital de Santa Maria (CHLN), Lisbon Academic Medical Centre, 1649-035 Lisbon, Portugal"}]},{"given":"Maria Jos\u00e9","family":"Santos","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, Edif\u00edcio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Avenida Egas Moniz, 1649-028 Lisbon, Portugal"},{"name":"Rheumatology Department, Hospital Garcia de Orta, 2805-267 Almada, 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