{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:24:15Z","timestamp":1740173055432,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Introduction.<\/jats:italic>This study aimed to assess the genetic determinants of poor outcome in Portuguese patients with juvenile idiopathic arthritis (JIA).<jats:italic>Methods.<\/jats:italic>Our study was conducted in Reuma.pt, the Rheumatic Diseases Portuguese Register, which includes patients with JIA. We collected prospectively patient and disease characteristics and a blood sample for DNA analysis. Poor prognosis was defined as CHAQ\/HAQ &gt;0.75 at the last visit and\/or the treatment with biological therapy. A selected panel of single nucleotide polymorphisms (SNPs) associated with susceptibility was studied to verify if there was association with poor prognosis.<jats:italic>Results.<\/jats:italic>Of the 812 patients with JIA registered in Reuma.pt, 267 had a blood sample and registered information used to define \u201cpoor prognosis.\u201d In univariate analysis, we found significant associations with poor prognosis for allele A of<jats:italic>TNFA1P3\/20<\/jats:italic>rs6920220, allele G of<jats:italic>TRAF1\/C5<\/jats:italic>rs3761847, and allele G of<jats:italic>PTPN2<\/jats:italic>rs7234029. In multivariate models, the associations with<jats:italic>TRAF1\/C5<\/jats:italic>(1.96 [1.17\u20133.3]) remained significant at the 5% level, while<jats:italic>TNFA1P3\/20<\/jats:italic>and<jats:italic>PTPN2<\/jats:italic>were no longer significant. Nevertheless, none of associations found was significant after the Bonferroni correction was applied.<jats:italic>Conclusion.<\/jats:italic>Our study does not confirm the association between a panel of selected SNP and poor prognosis in Portuguese patients with JIA.<\/jats:p>","DOI":"10.1155\/2015\/706515","type":"journal-article","created":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T17:06:31Z","timestamp":1443978391000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt"],"prefix":"10.1155","volume":"2015","author":[{"given":"Ana Filipa","family":"Mour\u00e3o","sequence":"first","affiliation":[{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, 1649-028 Lisbon, Portugal"},{"name":"Rheumatology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, 1349-019 Lisbon, Portugal"},{"name":"CEDOC, Faculdade de Ci\u00eancias Medicas da Universidade Nova de Lisboa, 1150-190 Lisbon, Portugal"}]},{"given":"Maria Jos\u00e9","family":"Santos","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, 1649-028 Lisbon, Portugal"},{"name":"Rheumatology Department, Hospital Garcia de Orta, 2801-951 Almada, Portugal"}]},{"given":"S\u00edlvia","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Portuguese Society of Rheumatology, 1800-033 Lisbon, Portugal"}]},{"given":"Filipa","family":"Oliveira-Ramos","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Lisbon Academic Medical Center, 1649-028 Lisbon, Portugal"}]},{"given":"Manuel","family":"Salgado","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Centro Universit\u00e1rio Hospitalar de Coimbra, 3041-801 Coimbra, Portugal"}]},{"given":"Paula","family":"Estanqueiro","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Centro Universit\u00e1rio Hospitalar de Coimbra, 3041-801 Coimbra, Portugal"}]},{"given":"Jos\u00e9","family":"Melo-Gomes","sequence":"additional","affiliation":[{"name":"Portuguese Society of Rheumatology, 1800-033 Lisbon, Portugal"},{"name":"Instituto Portugu\u00eas de Reumatologia, 1601-901 Lisbon, Portugal"}]},{"given":"Fernando","family":"Martins","sequence":"additional","affiliation":[{"name":"Portuguese Society of Rheumatology, 1800-033 Lisbon, Portugal"}]},{"given":"Ana","family":"Lopes","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, 1649-028 Lisbon, Portugal"}]},{"given":"Bruno Filipe","family":"Bettencourt","sequence":"additional","affiliation":[{"name":"Institute for Molecular and Cell Biology (IBMC), University of Porto, 4150-180 Porto, Portugal"},{"name":"Hospital de Santo Esp\u00edrito da Ilha Terceira, SEEBMO, Angra do Hero\u00edsmo, 9700-049 A\u00e7ores, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o 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