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In this study, the protective effects of pyrogallol, phloroglucinol, and myricetin on the yeast<jats:italic>Saccharomyces cerevisiae<\/jats:italic>were investigated. Pyrogallol and myricetin, which have a pyrogallol structure in the B ring, increased H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>resistance associated with a reduction in intracellular oxidation and protein carbonylation, whereas phloroglucinol did not exert protective effects. The acquisition of oxidative stress resistance in cells pretreated with pyrogallol and myricetin was not associated with an induction of endogenous antioxidant defences as assessed by the analysis of superoxide dismutase and catalase activities. However, myricetin, which provided greater stress resistance, prevented H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-induced glutathione oxidation. Moreover, myricetin increased the chronological lifespan of yeast lacking the mitochondrial superoxide dismutase (Sod2p), which exhibited a premature aging phenotype and oxidative stress sensitivity. These findings show that the presence of hydroxyl groups in the ortho position of the B ring in pyrogallol and myricetin contributes to the antioxidant protection afforded by these compounds. In addition, myricetin may alleviate aging-induced oxidative stress, particularly when redox homeostasis is compromised due to downregulation of endogenous defences present in mitochondria.<\/jats:p>","DOI":"10.1155\/2015\/782504","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T21:04:38Z","timestamp":1430168678000},"page":"1-10","source":"Crossref","is-referenced-by-count":45,"title":["Effect of Myricetin, Pyrogallol, and Phloroglucinol on Yeast Resistance to Oxidative Stress"],"prefix":"10.1155","volume":"2015","author":[{"given":"Vanda","family":"Mendes","sequence":"first","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen s\/n, 4200-135 Porto, Portugal"},{"name":"IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal"},{"name":"ICBAS, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, 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