{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:11:28Z","timestamp":1768471888306,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PEst-OE\/QUI\/UI0612\/2013"],"award-info":[{"award-number":["PEst-OE\/QUI\/UI0612\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Erica australis<\/jats:italic>L. (Ericaceae) is used in traditional medicine to treat many free-radical related ailments. In the present work, the stability and biological activity of the plant aqueous extracts submitted to an<jats:italic>in vitro<\/jats:italic>digestive process were investigated. Chemical stability was monitored by HPLC-DAD and LC-MS\/MS, while the bioactivities were evaluated through the inhibition of acetylcholinesterase (AChE) and DPPH radical scavenging activity. Both extracts, whose main components were flavonol glycosides, inhibited AChE, showing IC<jats:sub>50<\/jats:sub>values of 257.9 \u00b1 6.2\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL and 296.8 \u00b1 8.8\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL for the decoction and for the infusion, respectively. Significant radical scavenging activities were also revealed by both extracts, as denoted by the IC<jats:sub>50<\/jats:sub>values for the decoction, 6.7 \u00b1 0.1\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL, and for the infusion, 10.5 \u00b1 0.3\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL. After submission to gastric and pancreatic juices, no remarkable alterations in the composition or in the bioactivities were observed, suggesting that the extracts may pass through the gastrointestinal tract, keeping their composition and therefore their biological properties. Moreover, the bioavailability of the components of both extracts, as studied in a Caco-2 cell model, showed that compounds can permeate the membrane, which is a condition to exert their biological activities. Our results add further support to the potential of<jats:italic>E. australis<\/jats:italic>for its antioxidant and neuroprotective properties.<\/jats:p>","DOI":"10.1155\/2015\/854373","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T21:08:06Z","timestamp":1439413686000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Digestibility and Bioavailability of the Active Components of<i>Erica australis<\/i>L. Aqueous Extracts and Their Therapeutic Potential as Acetylcholinesterase Inhibitors"],"prefix":"10.1155","volume":"2015","author":[{"given":"Pilar","family":"Dias","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica e Bioqu\u00edmica, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade de Lisboa, Edif\u00edcio C8, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"Pedro L.","family":"Fal\u00e9","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica e Bioqu\u00edmica, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade de Lisboa, Edif\u00edcio C8, Campo Grande, 1749-016 Lisboa, Portugal"},{"name":"Institute of Pharmaceutical Science, King\u2019s College London, 150 Stamford Street, London SE1 9NH, UK"}]},{"given":"Alice","family":"Martins","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica e Bioqu\u00edmica, Departamento de Qu\u00edmica e Bioqu\u00edmica, 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