{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:49:20Z","timestamp":1774374560731,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>There is a clear association between the excessive and cumulative exposure to estrogens and the development of cancer in hormone\u2010sensitive tissues, such as the cervix. We studied the association of <jats:italic>CYP1A1 M1<\/jats:italic> (<jats:italic>rs4646903<\/jats:italic>) and <jats:italic>COMT<\/jats:italic> (<jats:italic>rs4680<\/jats:italic>) polymorphisms in 130 cervical cancer cases (c\u2010cancer) and 179 controls. The <jats:italic>CYP1A1<\/jats:italic> TT genotype was associated with a lower risk for c\u2010cancer (OR = 0.39, <jats:italic>p<\/jats:italic> = 0.002). The allele C of <jats:italic>CYP1A1<\/jats:italic> was a risk for c\u2010cancer (OR = 2.29, <jats:italic>p<\/jats:italic> = 0.002). Women with <jats:italic>COMT LL<\/jats:italic> genotype had a higher risk of developing c\u2010cancer (OR = 4.83, <jats:italic>p<\/jats:italic> &lt; 0.001). For the interaction of the <jats:italic>CYP1A1<\/jats:italic>&amp;<jats:italic>COMT<\/jats:italic>, we observed that TC&amp;HL genotypes had a greater risk for c\u2010cancer (OR = 6.07, <jats:italic>p<\/jats:italic> = 0.006) and TT&amp;HL genotypes had a protection effect (OR = 0.24, <jats:italic>p<\/jats:italic> &lt; 0.001). The <jats:italic>CYP1A1 TT<\/jats:italic> and <jats:italic>COMT LL<\/jats:italic> genotypes had higher estradiol levels in c\u2010cancer (<jats:italic>p<\/jats:italic> &lt; 0.001 and <jats:italic>p<\/jats:italic> = 0.037, resp.). C\u2010cancer is associated with less production of 2\u2010methoxy\u2010estradiol resultant of functional polymorphisms of <jats:italic>CYP1A1<\/jats:italic> and <jats:italic>COMT<\/jats:italic>, separately. <jats:italic>CYP1A1<\/jats:italic> and <jats:italic>COMT<\/jats:italic> work in a metabolic sequence and their interaction could lead to an alternative pathway of estrogen metabolism with production of 16\u2010OH\u2010estrone that is more proliferative.<\/jats:p>","DOI":"10.1155\/2016\/2769804","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T21:01:40Z","timestamp":1450731700000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Epistatic Interaction of <i>CYP1A1<\/i> and <i>COMT<\/i> Polymorphisms in Cervical 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