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Most recently, biologic agents have been proven to have therapeutic benefits in metastatic CRC alone or in association with standard chemotherapy. However, patients present different treatment responses, in terms of efficacy and toxicity; therefore, it is important to identify biological markers that can predict the response to therapy and help select patients that would benefit from specific regimens. In this paper, authors review CRC genetic markers that could be useful in predicting the sensitivity\/resistance to chemotherapy.<\/jats:p>","DOI":"10.1155\/2016\/6896024","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T17:02:08Z","timestamp":1470070928000},"page":"1-12","source":"Crossref","is-referenced-by-count":18,"title":["Predictive Biomarkers in Colorectal Cancer: From the Single Therapeutic Target to a Plethora of Options"],"prefix":"10.1155","volume":"2016","author":[{"given":"Daniela","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal"},{"name":"ICVS\/3B\u2019s-PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Campus of Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Adhemar","family":"Longatto-Filho","sequence":"additional","affiliation":[{"name":"Life and Health Sciences 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