{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:00:49Z","timestamp":1769832049258,"version":"3.49.0"},"reference-count":14,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic>To describe a case of anterior nodular scleritis, preceded by an anterior hypertensive uveitis, which was primarily caused by varicella zoster virus (VZV).<jats:italic>Case Report<\/jats:italic>. A 54-year-old woman presented with anterior uveitis of the right eye presumably caused by herpetic viral disease and was successfully treated. Two months later, she developed a nodular scleritis and started oral nonsteroidal anti-inflammatory without effect. A complete laboratory workup revealed positivity for HLA-B27; the infectious workup was negative. Therapy was changed to oral prednisolone and an incomplete improvement occurred. Therefore, a diagnostic anterior paracentesis was performed and the polymerase chain reaction (PCR) analysis revealed VZV. She was treated with valacyclovir and the oral prednisolone began to decrease; however, a marked worsening of the scleritis occurred with the reduction of the daily dose; subsequently, methotrexate was introduced allowing the suspension of the prednisolone and led to clinical resolution of the scleritis.<jats:italic>Conclusion.<\/jats:italic>This report of anterior nodular scleritis caused by VZV argues in favor of an underlying immune-mediated component, requiring immunosuppressive therapy for clinical resolution. The PCR analysis of the aqueous humor was revealed to be a valuable technique and should be considered in cases of scleritis with poor response to treatment.<\/jats:p>","DOI":"10.1155\/2016\/8519394","type":"journal-article","created":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T08:04:25Z","timestamp":1463731465000},"page":"1-3","source":"Crossref","is-referenced-by-count":6,"title":["Nodular Scleritis Associated with Herpes Zoster Virus: An Infectious and Immune-Mediated Process"],"prefix":"10.1155","volume":"2016","author":[{"given":"M\u00f3nica","family":"Loureiro","sequence":"first","affiliation":[{"name":"Vila Nova de Gaia\/Espinho Hospitalar Center, R. Concei\u00e7\u00e3o Fernandes, 4434-502 Vila Nova de Gaia, Portugal"},{"name":"Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal"}]},{"given":"Renata","family":"Rothwell","sequence":"additional","affiliation":[{"name":"Vila Nova de Gaia\/Espinho Hospitalar Center, R. Concei\u00e7\u00e3o Fernandes, 4434-502 Vila Nova de Gaia, Portugal"}]},{"given":"Sofia","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Vila Nova de Gaia\/Espinho Hospitalar Center, R. Concei\u00e7\u00e3o Fernandes, 4434-502 Vila Nova de Gaia, Portugal"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.60.3.163"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-2343-4"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6703099"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(00)00710-8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(94)31325-x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32269-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/753560"},{"issue":"6","key":"8","first-page":"1215","volume":"8","year":"2015","journal-title":"International Journal of Ophthalmology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76856-4"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.06.025"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.01.033"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2010.24.6.331"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1993.74"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00120-2"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2016\/8519394.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2016\/8519394.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2016\/8519394.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T03:19:53Z","timestamp":1471576793000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criopm\/2016\/8519394\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":14,"alternative-id":["8519394","8519394"],"URL":"https:\/\/doi.org\/10.1155\/2016\/8519394","relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"value":"2090-6722","type":"print"},{"value":"2090-6730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}