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For their use in human therapies, it is necessary to culture hMSC in xeno-free conditions. In this study, the impact that a xeno-free medium based on a human plasma derivate has on these properties was analysed. Bone marrow-derived hMSC preserved their immunosuppressive and immunostimulatory properties, as observed with in vitro assays with hMSC cocultured with mixed leukocyte reactions or with mitogen-stimulated leukocytes. Moreover, hMSC expanded in xeno-free medium were recruited by macrophages in both migration and invasion assays, which indicates that the cells maintained their chemotactic properties. These data suggest that xeno-free expanded hMSC preserved their immunomodulatory and chemotactic properties, indicating that the described xeno-free medium composition is a potential candidate to culture and expand hMSC for human cell therapies.<\/jats:p>","DOI":"10.1155\/2017\/2185351","type":"journal-article","created":{"date-parts":[[2017,5,14]],"date-time":"2017-05-14T17:00:36Z","timestamp":1494781236000},"page":"1-12","source":"Crossref","is-referenced-by-count":11,"title":["Human Bone Marrow Mesenchymal Stem\/Stromal Cells Preserve Their Immunomodulatory and Chemotactic Properties When Expanded in a Human Plasma Derived Xeno-Free Medium"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-9323","authenticated-orcid":true,"given":"A.","family":"Bl\u00e1zquez-Prunera","sequence":"first","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o Em Sa\u00fade, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Porto, Portugal"},{"name":"Faculdade de Engenharia, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6670-6004","authenticated-orcid":true,"given":"C. 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