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In this study, the oral yeast colonization of PD patients and the antifungal susceptibility profile of the isolated yeasts were accessed and correlated with fungal infection episodes in the following 4 years. Saliva yeast colonization was accessed in 21 PD patients and 27 healthy controls by growth in CHROMagar-Candida\u00ae and 18S rRNA\/ITS sequencing. PD patients presented a lower oral yeast prevalence when compared to controls, namely,<jats:italic>Candida albicans<\/jats:italic>. Other species were also isolated,<jats:italic>Candida glabrata<\/jats:italic>and<jats:italic>Candida carpophila<\/jats:italic>. The antifungal susceptibility profiles of these isolates revealed resistance to itraconazole, variable susceptibility to caspofungin, and higher MIC values of posaconazole compared to previous reports. The 4-year longitudinal evaluation of these patients revealed<jats:italic>Candida parapsilosis<\/jats:italic>and<jats:italic>Candida zeylanoides<\/jats:italic>as PD-related exit-site infectious agents, but no correlation was found with oral yeast colonization. This pilot study suggests that oral yeast colonization may represent a limited risk for fungal infection development in PD patients. Oral yeast isolates presented a variable antifungal susceptibility profile, which may suggest resistance to some second-line drugs, highlighting the importance of antifungal susceptibility assessment in the clinical practice.<\/jats:p>","DOI":"10.1155\/2017\/4846363","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T23:43:16Z","timestamp":1513899796000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Oral Yeast Colonization and Fungal Infections in Peritoneal Dialysis Patients: A Pilot Study"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-8546","authenticated-orcid":true,"given":"Liliana","family":"Sim\u00f5es-Silva","sequence":"first","affiliation":[{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"},{"name":"INEB-Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen 208, 4200-180 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