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Male Wistar rats were subjected to 5\/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment(<\/mml:mo>n<\/mml:mi>=<\/mml:mo>14<\/mml:mn>)<\/mml:mo><\/mml:math>; RMR + CAA: RMR rats treated with CAA(<\/mml:mo>n<\/mml:mi>=<\/mml:mo>13<\/mml:mn>)<\/mml:mo><\/mml:math>; SO: SO rats without treatment(<\/mml:mo>n<\/mml:mi>=<\/mml:mo>13<\/mml:mn>)<\/mml:mo><\/mml:math>; and SO + CAA: SO rats treated with CAA(<\/mml:mo>n<\/mml:mi>=<\/mml:mo>13<\/mml:mn>)<\/mml:mo><\/mml:math>. CAA was intraperitoneally administered in a dose of 0.23\u2009\u00b5<\/jats:italic>g\/Kg three times a week for six months.Results.<\/jats:italic>RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity(<\/mml:mo>p<\/mml:mi><<\/mml:mo>0.05<\/mml:mn>)<\/mml:mo><\/mml:math>and a decrease in reduced glutathione (GSH)\/oxidized glutathione (GSSG) ratio. CAA administration significantly increased catalase and GR activity(<\/mml:mo>p<\/mml:mi><<\/mml:mo>0.05<\/mml:mn>)<\/mml:mo><\/mml:math>and increased GSH\/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio. No significant differences were found between the RMR groups in any of the parameters of renal function. However, CAA administration slightly improves some parameters of renal function.Conclusions.<\/jats:italic>These data suggest that CAA could attenuate 5\/6 RMR-induced oxidative stress.<\/jats:p>","DOI":"10.1155\/2017\/5125980","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T23:04:27Z","timestamp":1487891067000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction"],"prefix":"10.1155","volume":"2017","author":[{"given":"Ant\u00f3nio","family":"Nogueira","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), Vila Real, Portugal"},{"name":"Department of Therapeutic and Diagnostic Technologies, Polytechnic Institute of Bragan\u00e7a (IPB), Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9729-7477","authenticated-orcid":true,"given":"Francisco","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Department of Biology and Environment, School of Life Science and Environment, UTAD, Vila Real, Portugal"},{"name":"Center for the Research and Technology of Agro-Environmental and Biological Science (CITAB), UTAD, Vila Real, Portugal"}]},{"given":"Maria Manuel","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Life Science and Environment, UTAD, Vila Real, Portugal"},{"name":"Chemistry Center of Vila Real (CQVR), UTAD, Vila Real, Portugal"}]},{"given":"Carlos Andr\u00e9","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Mathematics, School of Science and Technology, UTAD, Vila Real, Portugal"}]},{"given":"Bruno","family":"Cola\u00e7o","sequence":"additional","affiliation":[{"name":"Center for the Research and Technology of 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