{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:15:15Z","timestamp":1775891715131,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Associa\u00e7\u00e3o Nacional de Reumatologia, Portugal"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Cardiovascular (CV) diseases are a major cause of death in rheumatoid arthritis (RA) patients. Novel biomarkers [B-type natriuretic peptide (BNP); osteoprotegerin (OPG)\/receptor activator of nuclear factor-kappa B ligand (RANKL) ratio; and dickkopf-1 (DKK-1)] have been used in CV risk assessment. We analysed, in established RA patients, the presence of silent myocardial ischemia and its association with clinical variables, BNP, and bone and atheroma biomarkers.<jats:italic> Methods<\/jats:italic>. From a single-center tertiary referral hospital, RA patients asymptomatic for CV disease were submitted to myocardial perfusion scintigraphy (MPS) under adenosine stress and biomarkers measurements. Logistic regression was used to estimate crude odds ratios (OR) and 95% confidence intervals (CI).<jats:italic> Results<\/jats:italic>. In 189 patients, perfusion defects were frequent (25%) and associated with BNP \u2265 100\u2009pg\/mL (OR = 5.68; 95% CI: 2.038\u201315.830), fourth log OPG\/RANKL ratio quartile (OR = 2.88; 95% CI: 1.091\u20137.622), and DKK-1 \u2265 133\u2009pmol\/L (OR = 2.69; 95% CI: 1.058\u20136.840). Similar associations were confirmed in those with C-reactive protein &gt; or \u2264 3\u2009mg\/L. No relationship was found with the majority of traditional CV factors nor with disease variables.<jats:italic> Conclusions<\/jats:italic>. Our results corroborated the hypothesis that MPS could reveal subclinical CV dysfunction, supported the utility of BNP measurements as a screening tool, and put in perspective the potential usefulness of complementary approaches in CV risk assessment in RA patients.<\/jats:p>","DOI":"10.1155\/2017\/6509754","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T17:00:52Z","timestamp":1493830852000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["Myocardial Perfusion in Rheumatoid Arthritis Patients: Associations with Traditional Risk Factors and Novel Biomarkers"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-5465","authenticated-orcid":true,"given":"Miguel","family":"Bernardes","sequence":"first","affiliation":[{"name":"Department of Rheumatology, S\u00e3o Jo\u00e3o Hospital Center, Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Tiago S.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, S\u00e3o Jo\u00e3o Hospital Center, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-3261","authenticated-orcid":true,"given":"Maria Jo\u00e3o","family":"Martins","sequence":"additional","affiliation":[{"name":"i3s-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"},{"name":"Department of Biomedicine, Unit of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Raquel","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"EPI Unit-Institute of Public Health, University of Porto, Porto, Portugal"}]},{"given":"L\u00facia","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, S\u00e3o Jo\u00e3o Hospital Center, Porto, Portugal"}]},{"given":"Jorge G.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, S\u00e3o Jo\u00e3o Hospital Center, Porto, Portugal"}]},{"given":"Francisco","family":"Ventura","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Elisabete","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"i3s-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"},{"name":"Department of Cardiology, S\u00e3o Jo\u00e3o Hospital Center, Porto, 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