{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:15:18Z","timestamp":1775247318416,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To report the long-term clinical outcomes after switching from intravitreal bevacizumab or ranibizumab to aflibercept therapy in eyes with AMD. <jats:italic>Methods<\/jats:italic>. Retrospective analysis of changes in BCVA, SD-OCT image, and frequency of injections after 1, 2, and 3 years of follow-up. <jats:italic>Results<\/jats:italic>. 164 eyes were analyzed, 101 eyes switched from bevacizumab (group 1) and 63 from ranibizumab (group 2). One year after the switch, there was an overall nonsignificant mean decrease of 2 ETDRS letters in BCVA. Three years after, there was an overall mean decrease of 7 ETDRS letters, which was statistically significant. A significant improvement in the mean CRT was found at 1, 2, and 3 years. There was a significant decrease in the mean number of injections per year (7.8 to 6.5, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>) between the first and third year. <jats:italic>Conclusion<\/jats:italic>. Aflibercept can be useful in the management of refractory neovascular AMD, with a good morphological response. However, in the long-term, BCVA stabilization was not achieved.<\/jats:p>","DOI":"10.1155\/2017\/6835782","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T19:31:44Z","timestamp":1508441504000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["Switch to Aflibercept in the Treatment of Neovascular AMD: Long-Term Results"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2161-4680","authenticated-orcid":true,"given":"Pedro","family":"Neves Cardoso","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar de S\u00e3o Jo\u00e3o, University of Porto, Porto, Portugal"}]},{"given":"Ana Fernanda","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Jorge","family":"Meira","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar de S\u00e3o Jo\u00e3o, University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6831-5488","authenticated-orcid":true,"given":"Ana Catarina","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar de S\u00e3o Jo\u00e3o, University of Porto, Porto, Portugal"}]},{"given":"Manuel S.","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Departments of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Jo\u00e3o","family":"Pinheiro-Costa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar de S\u00e3o Jo\u00e3o, University of Porto, Porto, Portugal"},{"name":"Department of Anatomy, University of Porto, Porto, Portugal"}]},{"given":"Fernando","family":"Falc\u00e3o-Reis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar de S\u00e3o Jo\u00e3o, University of Porto, Porto, Portugal"},{"name":"Departments of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"\u00c2ngela M.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar de S\u00e3o Jo\u00e3o, University of Porto, Porto, Portugal"},{"name":"Departments of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/springerreference_61219"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/09286586.2016.1259422"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001576"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S97653"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303513"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1689"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2011.204685"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.07.007"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.7"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/497178"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0b013e31828e8551"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.02.009"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1159\/000381221"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000000751"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102673"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305327"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.03.045"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s90913"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4095852"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s125676"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.035"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/6835782.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/6835782.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/6835782.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T19:31:44Z","timestamp":1508441504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2017\/6835782\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":21,"alternative-id":["6835782","6835782"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6835782","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}