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The leaves of this plant are used in traditional medicine for medicinal purposes. Thus, the objective of this study was to perform a physicochemical characterization, identify the lipophilic antioxidants and fatty acids, and determine the microbiological quality and safety of <jats:italic>H. speciosa<\/jats:italic> leaves. In addition, the antioxidant, antimutagenic, and inhibitory activities of the ethanolic extract of <jats:italic>H. speciosa<\/jats:italic> leaves (EEHS) against enzymes related to neurodegenerative diseases, inflammation, obesity, and diabetes were investigated. Furthermore, this study aimed at assessing the <jats:italic>in vivo<\/jats:italic> effects of the EEHS on the glycemia of normoglycemic and diabetic Wistar rats. Physicochemical characterization was performed by colorimetry and gas\u2010liquid chromatography with flame ionization detection (GC\u2010FID). The total number of colonies of aerobic mesophiles, molds, and yeasts was determined. The total coliforms and <jats:italic>Escherichia coli<\/jats:italic> were counted using the SimPlates kit, and sulphite\u2010reducing <jats:italic>Clostridium<\/jats:italic> spores were quantified using the sulphite\u2010polymyxin\u2010sulfadiazine agar method. <jats:italic>Salmonella<\/jats:italic> spp. were detected using the 1\u20102 Test. The antioxidant activity of the EEHS was measured by its inhibition of 2,2\u2009<jats:sup>\u2032<\/jats:sup>\u2010azobis(2\u2010amidinopropane) dihydrochloride\u2010 (AAPH\u2010) induced oxidative hemolysis of human erythrocytes. The antimutagenic activity was determined using the Ames test. The acetylcholinesterase, butyrylcholinesterase, tyrosinase, hyaluronidase, lipase, <jats:italic>\u03b1<\/jats:italic>\u2010amylase, and <jats:italic>\u03b1<\/jats:italic>\u2010glycosidase enzyme\u2010inhibiting activities were assessed and compared with commercial controls. The <jats:italic>in vivo<\/jats:italic> effects of the EEHS were assessed using the oral glucose tolerance test in normoglycemic Wistar rats and measuring the blood glucose levels in diabetic rats. The results demonstrated physical\u2010chemical parameters of microbiological quality and safety in the leaves of <jats:italic>H. speciosa<\/jats:italic>, as well as antioxidant and antimutagenic activities and inhibition of enzymes related to neurodegenerative diseases, inflammation, obesity, and diabetes. In <jats:italic>in vivo<\/jats:italic> assays, it was shown that the normoglycemic rats challenged with glucose overload show significantly decreased blood glucose levels when treated with the EEHS. Taken together, the results ensure the microbiological quality and safety as well as showing the contents of carotenoids and polyunsaturated fatty acids of <jats:italic>H. speciosa<\/jats:italic> leaves. Additionally, the antioxidant, antimutagenic, anti\u2010inflammatory, anti\u2010Alzheimer\u2019s disease, anti\u2010Parkinson\u2019s disease, antiobesity, and antihyperglycemic activities of the EEHS were demonstrated.<\/jats:p>","DOI":"10.1155\/2018\/2976985","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T23:35:00Z","timestamp":1530228900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Physicochemical Characterization, Microbiological Quality and Safety, and Pharmacological Potential of <i>Hancornia speciosa<\/i> Gomes"],"prefix":"10.1155","volume":"2018","author":[{"given":"Uilson Pereira","family":"dos Santos","sequence":"first","affiliation":[]},{"given":"Georgina S.","family":"Tolentino","sequence":"additional","affiliation":[]},{"given":"Jorge 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