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Patients with NS and animal models of NS have vitamin D3 deficiency. The aim of the present study was to evaluate the influence of calcitriol on cardiac remodeling and local inflammatory state in PAN-NS rat model. Male Sprague-Dawley rats were injected with PAN or vehicle on day 0. PAN and control rats were divided into two subgroups for the administration of calcitriol (PAN-D and Ct-D groups) or the vehicle (PAN-V and Ct-V groups) during 21 days. On day 21, the renal function, metabolic balance, calcitriol and FGF-23 plasma levels, prohypertrophy and proinflammatory markers (ET-1, TGF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>1, TNF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>, and IL-1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>), and calcium signaling molecules (PLB and SERCA-2a) were evaluated. Twenty-one days after injection, PAN-V group presented cardiac hypertrophy and a modulation of proinflammatory markers local expression. Calcitriol treatment of PAN rats prevented cardiac hypertrophy and was associated with marked reduction in the cardiac expression levels of proinflammatory markers. Our results suggest that vitamin D3 deficiency in PAN-NS may contribute to cardiac remodeling and to the increase in local inflammatory activity. Calcitriol treatment prevents both cardiac repercussions and local inflammatory processes in PAN-NS.<\/jats:p>","DOI":"10.1155\/2018\/3609645","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T23:31:17Z","timestamp":1516750277000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Calcitriol Prevents Cardiovascular Repercussions in Puromycin Aminonucleoside-Induced Nephrotic Syndrome"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7020-0954","authenticated-orcid":true,"given":"Fernandes-Cerqueira","family":"C\u00e1tia","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, CMM L8:04, 171 76 Stockholm, Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-1848","authenticated-orcid":true,"given":"Quelhas-Santos","family":"Janete","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Engenharia Biom\u00e9dica (INEB-I3S), Nephrology and Infectious Diseases Research and Development Group, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-8075","authenticated-orcid":true,"given":"Sampaio-Maia","family":"Benedita","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Engenharia Biom\u00e9dica (INEB-I3S), Nephrology and Infectious Diseases Research and Development Group, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Faculty of Dental Medicine, University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-392 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-8546","authenticated-orcid":true,"given":"Sim\u00f5es-Silva","family":"Liliana","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Engenharia Biom\u00e9dica (INEB-I3S), Nephrology and Infectious Diseases Research and Development Group, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-1567","authenticated-orcid":true,"given":"Soares-Silva","family":"Isabel","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Engenharia Biom\u00e9dica (INEB-I3S), Nephrology and Infectious Diseases Research and Development Group, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Roncon-Albuquerque","family":"Roberto","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cardiothoracic Surgery General Practice, Faculty of Medicine, University of Porto, Al. Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1482-2024","authenticated-orcid":true,"given":"Pestana","family":"Manuel","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Engenharia Biom\u00e9dica (INEB-I3S), Nephrology and Infectious Diseases Research and Development Group, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Nephrology, S\u00e3o Jo\u00e3o Hospital Center, EPE, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Renal, Urological and Infectious Diseases, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]}],"member":"311","reference":[{"key":"1","year":"2008"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.292"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00785.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.12.2220"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1396-6"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002204"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-52-1-116"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/0221-8747(82)90003-0"},{"issue":"2","key":"9","first-page":"115","volume":"4","year":"1983","journal-title":"The International Journal of Pediatric Nephrology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1159\/000420135"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.294"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00651.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767140-00003"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004070573"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00224.2004"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1172\/jci113010"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi171"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1159\/000082868"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/397391"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.07.021"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.119602"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181761906"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1172\/jci118582"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1677\/joe-08-0241"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1487"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1172\/jci116834"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80742-6"},{"issue":"6","key":"28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s00467-003-1122-4","volume":"18","year":"2003","journal-title":"Pediatric Nephrology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(92)90010-T"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00656.2012"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-010-9274-4"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0933-8"},{"issue":"5","key":"33","first-page":"513","volume":"55","year":"2006","journal-title":"Physiological Research"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(98)00100-3"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13001"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.176"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/3609645.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/3609645.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/3609645.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T01:07:51Z","timestamp":1603674471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/3609645\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":36,"alternative-id":["3609645","3609645"],"URL":"https:\/\/doi.org\/10.1155\/2018\/3609645","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]}}}