{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:52:03Z","timestamp":1775206323331,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/MAT\/04106\/2013"],"award-info":[{"award-number":["UID\/MAT\/04106\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Health-related quality of life (HRQoL) impairment is common in pulmonary hypertension (PH), but its clinical predictors are not well established. This study aims to characterize the HRQoL of patients with pulmonary arterial hypertension (PAH) and other precapillary forms of PH (pcPH) and to explore its clinical correlates.<jats:italic> Materials and Methods<\/jats:italic>. A cross-sectional, observational study of patients with documented PAH and other forms of pcPH. Patients completed two patient-reported outcome measures (PROM): Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and Nottingham Health Profile (NHP). Clinical characteristics were retrieved from electronic medical records.<jats:italic> Results<\/jats:italic>. Mean CAMPHOR and NHP scores for the study population were indicative of a moderate HRQoL impairment. Patients in World Health Organisation Functional Classes (WHO FC) III\/IV showed significantly worse HRQoL. The main clinical correlates of HRQoL were WHO FC, 6-minute walking distance (6MWD), and Borg dyspnoea index. Overall quality of life (QoL), assessed through CAMPHOR\u2019s QoL domain, showed patterns comparable to HRQoL measured by both instruments.<jats:italic> Conclusions<\/jats:italic>. HRQoL, measured by two different PROMs, is impaired in Portuguese patients with PAH and other forms of pcPH, particularly in patients with increased disease severity. WHO FC, 6MWD, and Borg dyspnoea index are highly correlated with HRQoL and QoL.<\/jats:p>","DOI":"10.1155\/2018\/3924517","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T19:31:21Z","timestamp":1521487881000},"page":"1-10","source":"Crossref","is-referenced-by-count":32,"title":["Health-Related Quality of Life in Pulmonary Hypertension and Its Clinical Correlates: A Cross-Sectional Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4976-3781","authenticated-orcid":true,"given":"Ab\u00edlio","family":"Reis","sequence":"first","affiliation":[{"name":"Pulmonary Vascular Disease Unit, Medicine Department, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"M\u00e1rio","family":"Santos","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Disease Unit, Medicine Department, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Porto, Portugal"},{"name":"Cardiology Service, Medicine Department, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Porto, Portugal"},{"name":"Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine of Porto, Porto, Portugal"}]},{"given":"Margarida","family":"Vicente","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Aveiro, Aveiro, Portugal"}]},{"given":"In\u00eas","family":"Furtado","sequence":"additional","affiliation":[{"name":"Internal Medicine Service, Medicine Department, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"C\u00e9lia","family":"Cruz","sequence":"additional","affiliation":[{"name":"Internal Medicine Service, Medicine Department, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"Alzira","family":"Melo","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Disease Unit, Medicine Department, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"Lu\u00edsa","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Disease Unit, Medicine Department, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Porto, Portugal"},{"name":"Internal Medicine Service, Medicine Department, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"Fabienne","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Disease Unit, Medicine Department, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Porto, Portugal"},{"name":"Internal Medicine Service, Medicine Department, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"Pedro","family":"Sa-Couto","sequence":"additional","affiliation":[{"name":"Center for Research and Development in Mathematics and Applications, Department of Mathematics, University of Aveiro, Aveiro, 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