{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:21:33Z","timestamp":1740158493048,"version":"3.37.3"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chair on Pain Medicine of the Faculty of Medicine, University of Porto","award":["NORTE-01-0145-FEDER-000008","NORTE-01-0145-FEDER-000016"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000008","NORTE-01-0145-FEDER-000016"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000008","NORTE-01-0145-FEDER-000016"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000008","NORTE-01-0145-FEDER-000016"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000008","NORTE-01-0145-FEDER-000016"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000008","NORTE-01-0145-FEDER-000016"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Treatment"],"published-print":{"date-parts":[[2018,7,10]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. High rates of opioid use for chronic noncancer pain (CNCP) have been reported worldwide, despite its association with adverse events, inappropriate use, and limited analgesic effect. Opioid-induced constipation (OIC) is the most prevalent and disabling adverse effect associated with opioid therapy. Our aim was to assess the incidence, health related quality of life (HRQOL), and disability in OIC patients.<jats:italic> Methods<\/jats:italic>. A prospective cohort study was performed, with 6 months of follow-up, of adult CNCP patients consecutively admitted in 4 multidisciplinary pain clinics (MPC). Demographic and clinical data have been collected. Brief Pain Inventory (BPI) and Short version of Treatment Outcomes in Pain Survey (S-TOPS) were used to measure functional outcomes and HRQOL. OIC was assessed using Bowel Function Index (BFI).<jats:italic> Results<\/jats:italic>. 694 patients were recruited. OIC prevalence at baseline was 25.8%. At 6 months, OIC incidence was 24.8%. Female gender (OR = 1.65, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.039<\/mml:mn><\/mml:math>), opioid therapy (OR 1.65, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.026<\/mml:mn><\/mml:math>), and interference pain score on BPI (OR 1.10, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.009<\/mml:mn><\/mml:math>) were identified as OIC independent predictors. OIC patients presented higher disability and pain interference and severity scores. OIC patients reported less satisfaction with outcome (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.038<\/mml:mn><\/mml:math>).<jats:italic> Discussion<\/jats:italic>. Constipation is a common adverse event among opioid users with major functional and quality of life impairment. These findings emphasise the need of OIC adequate assessment and management.<\/jats:p>","DOI":"10.1155\/2018\/5704627","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T23:36:07Z","timestamp":1531265767000},"page":"1-11","source":"Crossref","is-referenced-by-count":9,"title":["Incidence and Health Related Quality of Life of Opioid-Induced Constipation in Chronic Noncancer Pain Patients: A Prospective Multicentre Cohort Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-8833","authenticated-orcid":true,"given":"Dalila R.","family":"Veiga","sequence":"first","affiliation":[{"name":"Anesthesiology Department, Chronic Pain Center, Centro Hospitalar Universit\u00e1rio do Porto, Largo do Prof. Abel Salazar, 4099-001 Porto, Portugal"}]},{"given":"Liliane","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Centro Nacional de Observa\u00e7\u00e3o em Dor, OBSERVDOR, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Rute","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina, Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, Portugal"},{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal"},{"name":"Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-7409","authenticated-orcid":true,"given":"Jos\u00e9 C.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Centro Nacional de Observa\u00e7\u00e3o em Dor, OBSERVDOR, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Departamento de Biomedicina, Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, Portugal"},{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Portugal"},{"name":"Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal Faculty of Medicine University of Porto, Department of Biomedicine, Porto, Portugal"}]},{"given":"Lu\u00eds F.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Center for Health Technology and Services Research (CINTESIS); Faculdade de Medicina da Universidade do Porto, Departamento de Medicina da Comunidade Informa\u00e7\u00e3o e Decis\u00e3o em Sa\u00fade (MEDCIDS); Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, 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