{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:29:30Z","timestamp":1759332570501,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\/MEC","award":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"],"award-info":[{"award-number":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"],"award-info":[{"award-number":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PT2020 Partnership Agreement","award":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"],"award-info":[{"award-number":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"]}]},{"name":"COMPETE 2020","award":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"],"award-info":[{"award-number":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"]}]},{"name":"COMPETE 2020","award":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"],"award-info":[{"award-number":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"]}]},{"name":"COMPETE 2020","award":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"],"award-info":[{"award-number":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"]}]},{"name":"COMPETE 2020","award":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"],"award-info":[{"award-number":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"],"award-info":[{"award-number":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"],"award-info":[{"award-number":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"],"award-info":[{"award-number":["UID\/BIA\/04004\/2013","UID\/QUI\/00062\/2013","POCI\/01\/0145\/FEDER\/007265","UID\/QUI\/50006\/2013","SFRH\/BPD\/100865\/2014","SFRH\/BPD\/74299\/2010","SFRH\/BD\/100865\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Agronomy"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Chromium (Cr) contamination in arable soils and irrigating water remains a priority, particularly due to the challenges posed to crop production and food safety. Long-term Cr(VI) effects remain less addressed than short-term ones, particularly regarding organ-specific genotoxic profiles. Here we used the crop<jats:italic> Lactuca sativa<\/jats:italic> growing in a protected horticultural system and irrigated for 21 days with Cr(VI) (up to 200\u2009mg\/L). Besides the oxidative stress, the genotoxicity was evaluated. Shoots and roots showed distinctive oxidative stress status and genotoxic effects, in a dose-dependent manner. While 50\u2009mg\/L stimulated antioxidant activities and no major genotoxic effects were found, plants exposed to \u2265150 showed an increase of oxidative disorders, together with cytostatic and DNA damage effects, and some mitotic impairment. Leaves showed less oxidative signs at 50\u2009mg\/L, while at 150\/200\u2009mg\/L the antioxidant battery was stimulated. In Cr treated plants, the highest dose increased the DNA damage, reinforcing the idea that DNA breaks were related to mitotic disorders in higher doses. In conclusion, long-term exposure data show a highly responsive root, with a quadratic response meaning higher defenses at lower Cr doses, and higher oxidative and DNA damage and cytostatic effect at a higher dose.<\/jats:p>","DOI":"10.1155\/2018\/5738014","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T19:32:09Z","timestamp":1524166329000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Bridging a Gap between Cr(VI)-Induced Oxidative Stress and Genotoxicity in Lettuce Organs after a Long-Term Exposure"],"prefix":"10.1155","volume":"2018","author":[{"given":"Cristina","family":"Monteiro","sequence":"first","affiliation":[{"name":"Laboratory of Biotechnology and Cytomics, University of Aveiro, Campo Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-9227","authenticated-orcid":true,"given":"Sara","family":"Sario","sequence":"additional","affiliation":[{"name":"Department of Biology, LAQV\/REQUIMTE, Faculty of Sciences, University of Porto, Rua Campo Alegre, 4169-007 Porto, Portugal"}]},{"given":"Rafael","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Biology, LAQV\/REQUIMTE, Faculty of Sciences, University of Porto, Rua Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1695-2762","authenticated-orcid":true,"given":"Nuno","family":"Mariz-Ponte","sequence":"additional","affiliation":[{"name":"Department of Biology, LAQV\/REQUIMTE, Faculty of Sciences, University of Porto, Rua Campo Alegre, 4169-007 Porto, Portugal"}]},{"given":"S\u00f3nia","family":"Silva","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Helena","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Cytomics, University of Aveiro, Campo Santiago, 3810-193 Aveiro, Portugal"}]},{"given":"Ver\u00f3nica","family":"Bastos","sequence":"additional","affiliation":[{"name":"Department of Biology, LAQV\/REQUIMTE, Faculty of Sciences, University of Porto, Rua Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4129-6381","authenticated-orcid":true,"given":"Concei\u00e7\u00e3o","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Biology, LAQV\/REQUIMTE, Faculty of Sciences, University of Porto, Rua Campo Alegre, 4169-007 Porto, Portugal"}]},{"given":"Maria Celeste","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Biology, LAQV\/REQUIMTE, Faculty of Sciences, University of Porto, Rua Campo Alegre, 4169-007 Porto, Portugal"},{"name":"Center for Functional Ecology (CEF), Department of Life Science, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1016\/j.chemosphere.2017.03.074"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1590\/S1677-04202005000100008"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1016\/j.ecoenv.2017.01.042"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1016\/j.chemosphere.2017.11.062"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1186\/s12864-016-3200-6"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1007\/s11356-016-6735-9"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1007\/s10725-013-9816-5"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1016\/j.plaphy.2016.08.014"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.3390\/ijms160715852"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1016\/j.chemosphere.2014.06.029"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1016\/j.envpol.2017.05.012"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1016\/j.jplph.2017.11.013"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1016\/j.ecoenv.2015.05.011"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1007\/s11356-015-4396-8"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1016\/j.ecoenv.2017.07.016"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.1016\/j.ecoenv.2017.06.010"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.3199\/iscb.11.44"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1007\/s11270-014-1933-x"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.1007\/s11103-014-0219-4"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1021\/tx2001465"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.1080\/01904160500324808"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.1016\/j.jplph.2013.01.015"},{"doi-asserted-by":"publisher","key":"23","DOI":"10.1016\/j.scienta.2004.04.023"},{"doi-asserted-by":"publisher","key":"24","DOI":"10.1007\/s10722-007-9268-8"},{"doi-asserted-by":"publisher","key":"25","DOI":"10.1016\/j.mrgentox.2008.02.009"},{"doi-asserted-by":"publisher","key":"26","DOI":"10.1021\/tx300039t"},{"doi-asserted-by":"publisher","key":"27","DOI":"10.1016\/j.plaphy.2012.01.013"},{"doi-asserted-by":"publisher","key":"28","DOI":"10.1590\/S1677-04202012000300007"},{"doi-asserted-by":"publisher","key":"29","DOI":"10.5897\/AJB11.2402"},{"doi-asserted-by":"publisher","key":"30","DOI":"10.1016\/j.envint.2005.02.003"},{"issue":"1","key":"31","first-page":"7","volume":"48","year":"2006","journal-title":"Acta Biologica Cracoviensia Series Botanica"},{"doi-asserted-by":"publisher","key":"32","DOI":"10.1016\/s1001-0742(08)62552-8"},{"doi-asserted-by":"publisher","key":"33","DOI":"10.1155\/2015\/756120"},{"doi-asserted-by":"publisher","key":"34","DOI":"10.1016\/j.plaphy.2016.06.030"},{"doi-asserted-by":"publisher","key":"35","DOI":"10.1016\/j.cbi.2010.04.018"},{"doi-asserted-by":"publisher","key":"36","DOI":"10.1007\/s12038-012-9218-2"},{"doi-asserted-by":"publisher","key":"37","DOI":"10.1007\/s00204-008-0313-y"}],"container-title":["International Journal of Agronomy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ija\/2018\/5738014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ija\/2018\/5738014.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ija\/2018\/5738014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T19:32:17Z","timestamp":1524166337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ija\/2018\/5738014\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":37,"alternative-id":["5738014","5738014"],"URL":"https:\/\/doi.org\/10.1155\/2018\/5738014","relation":{},"ISSN":["1687-8159","1687-8167"],"issn-type":[{"type":"print","value":"1687-8159"},{"type":"electronic","value":"1687-8167"}],"subject":[],"published":{"date-parts":[[2018]]}}}