{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T23:14:44Z","timestamp":1769382884265,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/78413\/2011"],"award-info":[{"award-number":["SFRH\/BD\/78413\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. The efficacy of cardiopulmonary exercise testing (CPET) to determining exercise intensity has not been established in Amyotrophic Lateral Sclerosis (ALS). We studied this intervention.<jats:italic> Methods.<\/jats:italic> We included 48 ALS patients randomized in 2 groups: G1 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">24<\/mml:mn><\/mml:math>), exercise intensity leveled by CPET; G2 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">24<\/mml:mn><\/mml:math>), standard care limited by fatigue, during 6 months. ALS functional scale (ALSFRS-R) and forced vital capacity (FVC) were performed every 3 months; CPET was done at admission (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>T<\/mml:mi><mml:mn fontstyle=\"italic\">1<\/mml:mn><\/mml:math>) and 6 months later (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>T<\/mml:mi><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:math>). We registered oxygen uptake, carbon dioxide output, and ventilation at anaerobic threshold and at peak effort. Primary outcome was functional change. We used parametric statistics for comparisons and multiple regression analyses to identify independent predictors of functional decline.<jats:italic> Results<\/jats:italic>. At <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>T<\/mml:mi><mml:mn fontstyle=\"italic\">1<\/mml:mn><\/mml:math> both groups were identical, except for higher FVC in G1 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>). At <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>T<\/mml:mi><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:math>, ALSFRS-R was higher (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.035<\/mml:mn><\/mml:math>) in G1. Gas exchange variables at <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>T<\/mml:mi><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:math> did not change in G1 but had significant differences in G2 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). Multiregression analyses showed the Spinal ALSFRS-R slope and Intervention group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) as significant predictors of ALSFRS-R at <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>T<\/mml:mi><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:math>.<jats:italic> Conclusion<\/jats:italic>. Aerobic exercise defined by CPET is feasible and can improve functional outcome in ALS. This trial is registered with Clinical trials.gov ID: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03326622\">NCT03326622<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2018\/8218697","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T18:36:29Z","timestamp":1517423789000},"page":"1-10","source":"Crossref","is-referenced-by-count":34,"title":["The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7592-1718","authenticated-orcid":true,"given":"Anna Caroline Marques","family":"Braga","sequence":"first","affiliation":[{"name":"Translational and Clinical Physiology Unit, Molecular Medicine Institute, Faculty of Medicine, University of Lisbon, Lisbon, Portugal"}]},{"given":"Anabela","family":"Pinto","sequence":"additional","affiliation":[{"name":"Translational and Clinical Physiology Unit, Molecular Medicine Institute, Faculty of Medicine, University of Lisbon, Lisbon, Portugal"},{"name":"Department of Physical Medicine and Rehabilitation, Hospital Santa Maria-CHLN, Faculty of Medicine, University of Lisbon, Lisbon, Portugal"},{"name":"Department of Neurosciences, Hospital Santa Maria-CHLN, Lisbon, Portugal"}]},{"given":"Susana","family":"Pinto","sequence":"additional","affiliation":[{"name":"Translational and Clinical Physiology Unit, Molecular Medicine Institute, Faculty of Medicine, University of Lisbon, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-0158","authenticated-orcid":true,"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Translational and Clinical Physiology Unit, Molecular Medicine Institute, Faculty of Medicine, University of Lisbon, Lisbon, 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