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In this work, a crude hydroalcoholic extract (CHE) of <jats:italic>C. brasiliense<\/jats:italic> leaves and its resulting fractions in hexane (HF), chloroform (CF), ethyl acetate (EAF), and butanol (BF) were investigated for their antioxidant properties and anticholinesterase activities. The antioxidant properties were evaluated by free radical scavenging and electroanalytical assays, which were further correlated with the total phenolic content and LC\u2010MS results. The acetylcholinesterase and butyrylcholinesterase inhibitory activities were examined using Ellman\u2019s colorimetric method. The LC\u2010MS analysis of EAF revealed the presence of gallic acid and quercetin. CHE and its fractions, EAF and BF, showed anticholinesterase and antioxidant activities, suggesting the association of both effects with the phenolic content. In addition, behavioral tests performed with CHE (10, 100, and 300\u2009mg\/kg) showed that it prevented mice memory impairment which resulted from aluminium intake. Moreover, CHE inhibited brain lipid peroxidation and acetyl and butyryl\u2010cholinesterase activities and the extract\u2019s neuroprotective effect was reflected at the microscopic level. Therefore, the leaves of pequi are a potential source of phenolic antioxidants and can be potentially used in treatments of memory dysfunctions, such as those associated with neurodegenerative disorders.<\/jats:p>","DOI":"10.1155\/2018\/9842908","type":"journal-article","created":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T23:32:06Z","timestamp":1540164726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Neuroprotective Effect of <i>Caryocar brasiliense<\/i> Camb. 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