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Advances in pluripotent stem cell (PSC) technology have promoted the <jats:italic>in vitro<\/jats:italic> recreation of processes involved in human morphogenesis. The development of organoids from human PSCs represents one reliable source for modeling a large spectrum of human disorders, as well as a promising approach for drug screening and toxicological tests. Based on the \u201cself-organization\u201d capacity of stem cells, different PSC-derived organoids have been created; however, considerable differences between <jats:italic>in vitro<\/jats:italic>-generated PSC-derived organoids and their <jats:italic>in vivo<\/jats:italic> counterparts have been reported. Advances in the bioengineering field have allowed the manipulation of different components, including cellular and noncellular factors, to better mimic the <jats:italic>in vivo<\/jats:italic> microenvironment. In this review, we focus on different examples of bioengineering approaches used to promote the self-organization of stem cells, including assembly, patterning, and morphogenesis <jats:italic>in vitro<\/jats:italic>, contributing to tissue-like structure formation.<\/jats:p>","DOI":"10.1155\/2019\/4508470","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T19:41:59Z","timestamp":1555616519000},"page":"1-17","source":"Crossref","is-referenced-by-count":29,"title":["Design Principles for Pluripotent Stem Cell-Derived Organoid Engineering"],"prefix":"10.1155","volume":"2019","author":[{"given":"Teresa P.","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Bioengineering and iBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. 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