{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:24:45Z","timestamp":1765369485159,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T00:00:00Z","timestamp":1570924800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,10,13]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate the predictors for subretinal fluid resorption in patients with chronic central serous retinopathy (cCSR) submitted to half-dose photodynamic therapy (HD-PDT). <jats:italic>Methods<\/jats:italic>. Observational, longitudinal, and retrospective study of patients with cCSR submitted to HD-PDT in a tertiary ophthalmology department in Portugal between January 2015 and February 2018. Best-corrected visual acuity (BCVA) and SD-OCT at baseline and 12\u2009\u00b1\u20093 months after treatment were performed. The central macular thickness (CMT), outer nuclear layer (ONL) thickness, integrity of the external limiting membrane (ELM), ellipsoid (EZ) and interdigitation zone (IZ), subretinal fluid (SFR) height, and choroidal thickness (CT) were evaluated. Patients were classified into responders and nonresponders based on SRF resorption. <jats:italic>Results<\/jats:italic>. Sixty-one eyes of 42 patients were included; 75.4% were classified as responders. Final BCVA was significantly better in responders (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:mrow><\/mml:math>). The baseline ONL was thicker (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>) and intact ELM (67.2% vs. 16.4%), EZ (49.2% vs. 8.2%), and IZ (31.2% vs. 1.6%) were more prevalent in responders than in nonresponders. Anatomic response was correlated with a thicker ONL (rs (59)\u2009=\u20090.416, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:msup><mml:mrow><mml:mn>0.001<\/mml:mn><\/mml:mrow><mml:mrow><mml:mi>\u2217<\/mml:mi><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>), intact ELM (rs (59)\u2009=\u20090.261, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:msup><mml:mrow><mml:mn>0.04<\/mml:mn><\/mml:mrow><mml:mrow><mml:mi>\u2217<\/mml:mi><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>), EZ (rs (59)\u2009=\u20090.278, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:msup><mml:mrow><mml:mn>0.03<\/mml:mn><\/mml:mrow><mml:mrow><mml:mi>\u2217<\/mml:mi><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>), and IZ (rs (59)\u2009=\u20090.318, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:msup><mml:mrow><mml:mn>0.01<\/mml:mn><\/mml:mrow><mml:mrow><mml:mi>\u2217<\/mml:mi><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>). Binary logistic regression showed that a thicker ONL thickness increased the chance of an anatomic response to HD-PDT. The other evaluated retinal layers did not have statistical significance in the binary regression model. <jats:italic>Conclusions<\/jats:italic>. cCSR responders to HD-PDT have a better final BCVA, a thicker baseline ONL, and an intact baseline ELM, EZ, and IZ. However, ONL was the only predictor in a logistic regression model for SRF resorption.<\/jats:p>","DOI":"10.1155\/2019\/5859063","type":"journal-article","created":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T19:32:53Z","timestamp":1570995173000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Outer Nuclear Layer as the Main Predictor to Anatomic Response to Half Dose Photodynamic Therapy in Chronic Central Serous Retinopathy"],"prefix":"10.1155","volume":"2019","author":[{"given":"Keissy","family":"Sousa","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Hospital de Braga, Braga, Portugal"},{"name":"Ophthalmology Department, Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, Porto, Portugal"}]},{"given":"Ana Rita","family":"Viana","sequence":"additional","affiliation":[{"name":"Medicine School, Universidade do Minho, Braga, Portugal"}]},{"given":"Joana","family":"Pires","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital de Braga, Braga, Portugal"}]},{"given":"Carla","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital de Braga, Braga, Portugal"}]},{"given":"Lara","family":"Queir\u00f3s","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital Cuf Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4718-0910","authenticated-orcid":true,"given":"Manuel","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, Porto, Portugal"},{"name":"Ophthalmology Department, Hospital Cuf Porto, Porto, Portugal"},{"name":"Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(67)90027-x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-016-3403-1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000000001"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2017.1416414"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2695-2"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0b013e3182247535"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15256"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2289-4"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.01.018"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.08.037"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0b013e318263d11f"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.03.043"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2270-2"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-009-1104-8"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S38363"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.090282"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.11.040"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.04.021"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4086-6"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3513794"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1159\/000484100"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000002040"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000001655"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-018-0950-y"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002445"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/5859063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/5859063.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/5859063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T19:32:55Z","timestamp":1570995175000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2019\/5859063\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,13]]},"references-count":25,"alternative-id":["5859063","5859063"],"URL":"https:\/\/doi.org\/10.1155\/2019\/5859063","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"type":"print","value":"2090-004X"},{"type":"electronic","value":"2090-0058"}],"subject":[],"published":{"date-parts":[[2019,10,13]]}}}