{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:57:12Z","timestamp":1768276632847,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/4255\/2020"],"award-info":[{"award-number":["UIDB\/4255\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Hypertension"],"published-print":{"date-parts":[[2020,12,22]]},"abstract":"<jats:p>Background. The long-term prognosis and transition towards sustained ambulatory hypertension (SHT) of white-coat hypertension (WCHT) remain uncertain particularly in those with both normal nighttime and daytime blood pressure (BP) values. Different classification criteria and the use of antihypertensive drugs may contribute to conflicting results. Patients and Methods. We prospectively evaluated for a 7.1 year transition to SHT in 899 nondiabetic subjects free from cardiovascular (CV) events: normotensive (NT) (n\u2009=\u2009344; 52, 9% female; ageing 48\u2009\u00b1\u200914 years); untreated WCHT (UnWCHT n\u2009=\u2009399; 50, 1% female; ageing 51\u2009\u00b1\u200914 years); and treated WCHT with antihypertensive drugs after baseline (TxWCHT n\u2009=\u2009156; 54, 4% female; ageing 51\u2009\u00b1\u200915 years). All underwent 24\u2009h ambulatory BP monitoring (24\u2009h-ABPM) at baseline, at 30 to 60 months, and at 70 to 120 months thereafter. WCHT was at baseline (with no treatment) as office BP\u2009\u2265\u2009140\/or 90\u2009mm\u00b7Hg, daytime BP\u2009&lt;\u2009135\/85\u2009mm\u00b7Hg, and nighttime BP\u2009&lt;\u2009120\/70\u2009mm\u00b7Hg. Development of SHT was considered if daytime BP\u2009\u2265\u2009135\/or 85\u2009mm Hg and\/or nighttime BP\u2009\u2265\u2009120\/or 70\u2009mm\u00b7Hg. Results. Baseline metabolic parameters did not differ among groups. At 30\u201360 months and at the end of follow-up, development of SHT occurred, respectively, in NT (3.8% (n\u2009=\u200913) and 9.6% (n\u2009=\u200933)) and in UnWCHT (10.1% (n\u2009=\u200940) and 16.5% (n\u2009=\u200966)) (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.009<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The mean annual increase of average 24\u2009h-systolic BP was 0.48\u2009+\u20090.93 in NT and 0.73\u2009+\u20091.06 in UnWCHT, whereas annual SBP in office increased in NT by 1.2\u2009+\u20090.95 but decreased in UnWCHT by 1.36\u2009+\u20091.35\u2009mm Hg (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.01<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Conclusion. Untreated WCHT patients exhibit a faster and a higher risk of developing SHT compared to NT with TxWCHT assuming an intermediate position between them.<\/jats:p>","DOI":"10.1155\/2020\/8817544","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T20:50:06Z","timestamp":1608670206000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Long-Term Risk of Progression to Sustained Hypertension in White-Coat Hypertension with Normal Night-Time Blood Pressure Values"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1367-9617","authenticated-orcid":true,"given":"Jo\u00e3o","family":"Faria","sequence":"first","affiliation":[{"name":"Department Medicine and Cintesis, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9526-3123","authenticated-orcid":true,"given":"Jos\u00e9","family":"Mesquita Bastos","sequence":"additional","affiliation":[{"name":"Health School of Aveiro University, Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-5071","authenticated-orcid":true,"given":"Susana","family":"Bertoquini","sequence":"additional","affiliation":[{"name":"Hypertension Unit, Hospital Pedro Hispano, ULS, Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5373-5030","authenticated-orcid":true,"given":"Jos\u00e9","family":"Silva","sequence":"additional","affiliation":[{"name":"Hypertension Unit, Hospital Pedro Hispano, ULS, Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-7217","authenticated-orcid":true,"given":"Jorge","family":"Pol\u00f3nia","sequence":"additional","affiliation":[{"name":"Department Medicine and Cintesis, Faculty of Medicine, University of Porto, Porto, Portugal"}]}],"member":"311","reference":[{"issue":"33","key":"1","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"B. 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