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The treatment and control of schistosomiasis rely on a single drug, praziquantel (PZQ). Despite its efficacy, treatment with PZQ presents some major drawbacks including an inability of the chemotherapy to reverse disease-induced fibrosis and the prospect of the emergence of drug resistance. Here, we investigated a novel therapeutic approach with antioxidant biomolecules in combination with PZQ against the adult developmental stage of <jats:italic>Schistosoma mansoni<\/jats:italic> and oviposition <jats:italic>in vitro<\/jats:italic>, given that this therapeutic approach achieved synergistic\/additive activity against larval schistosomes. The antioxidants curcumin and oxadiazole <jats:italic>per se<\/jats:italic> exhibited antischistosomal activity against adult worms leading to severe morphological alterations and death. Additionally, the antioxidant flavone combined with vandetanib or imatinib improved antischistosomal activity against adult forms. By contrast, however, these antioxidant-anthelmintic combinations were not as effective against adults in comparison to larval schistosomes. Nevertheless, the antioxidants alone or combined with drugs inhibited oviposition.<\/jats:p>","DOI":"10.1155\/2020\/8843808","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T23:45:28Z","timestamp":1596757528000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["Activity of Combinations of Antioxidants and Anthelmintic Drugs against the Adult Stage of <i>Schistosoma mansoni<\/i>"],"prefix":"10.1155","volume":"2020","author":[{"given":"Maria Jo\u00e3o","family":"Gouveia","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology and Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Center for the Study in Animal Science, University of Porto (CECA\/ICETA), Rua de D. Manuel II, Apartado 55142, 4051-401 Porto, Portugal"}]},{"given":"Paul J.","family":"Brindley","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology & Tropical Medicine, Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037, USA"}]},{"given":"F\u00e1tima","family":"G\u00e4rtner","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology and Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua J\u00falio Amaral de Carvalho 45, 4200-135 Porto, Portugal"},{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-1042","authenticated-orcid":true,"given":"Nuno","family":"Vale","sequence":"additional","affiliation":[{"name":"OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Pl\u00e1cido da Costa, 4200-450 Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, Al. 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