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Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during figurative language comprehension. The method is aimed at mapping significant causal relationships across language brain networks, captured by functional near-infrared spectroscopy measurements (fNIRS): (i) definition of regions of interest (ROIs) based on significant channels extracted from spatial activation maps; (ii) inspection of significant causal relationships in temporal resolution, exploring the experimental task agreement; and (iii) early identification of stronger causal relationships that guide neuromodulation intervention, targeting impaired connectivity pathways. Our results propose top-down mechanisms responsible for perceptive-attention engagement in the left anterior frontal cortex and bottom-up mechanism in the right hemispheres during the semantic integration of figurative language. Moreover, the interhemispheric directional flow suggests a right hemisphere engagement in decoding unfamiliar literal sentences and fine-grained integration guided by the left hemisphere to reduce ambiguity in meaningless words. Finally, bottom-up mechanisms seem activated by logographic-semantic processing in literal meanings and memory storage centres in meaningless comprehension. To sum up, our main findings reveal that the Granger Prediction Estimation (GPE) integrated strategy proposes an effective link between assessment and intervention, capable of enhancing the efficiency of the treatment in language disorders and reducing the neuromodulation side effects.<\/jats:p>","DOI":"10.1155\/2020\/8882207","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T18:22:52Z","timestamp":1602008572000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-4519","authenticated-orcid":true,"given":"Tania Alexandra","family":"Couto","sequence":"first","affiliation":[{"name":"Centre for Cognitive and Brain Sciences, University of Macau, Macau S.A.R., China"},{"name":"Faculty of Health Sciences, University of Macau, Macau S.A.R.., China"}]},{"given":"Shiyang","family":"Xu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3814-6879","authenticated-orcid":true,"given":"Paulo Armada","family":"da Silva","sequence":"additional","affiliation":[{"name":"Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-3841","authenticated-orcid":true,"given":"Chenggang","family":"Wu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1055-9495","authenticated-orcid":true,"given":"Karl","family":"Neergaard","sequence":"additional","affiliation":[{"name":"Centre for Cognitive and Brain Sciences, University of Macau, Macau S.A.R., China"}]},{"given":"Meng-Yun","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Yutao","family":"Xiang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-6263","authenticated-orcid":true,"given":"Zhen","family":"Yuan","sequence":"additional","affiliation":[]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.01627"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2017.11.015"},{"article-title":"In reply to Faes et al. and Barnett et al. regarding \u2018a study of problems encountered in Granger causality analysis from a neuroscience perspective","year":"2017","author":"P. 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