{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:58:44Z","timestamp":1776895124229,"version":"3.51.2"},"reference-count":84,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T00:00:00Z","timestamp":1640476800000},"content-version":"vor","delay-in-days":359,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","award":["2021.06746.BD"],"award-info":[{"award-number":["2021.06746.BD"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Styrylchromones (SC) are a group of oxygen\u2010containing heterocyclic compounds, which are characterized by the attachment of a styryl group to the chromone core. SC can be found in nature or can be chemically synthesized in the laboratory. As their presence in nature is scarce, the synthetic origin is the most common. Two types of SC are known: 2\u2010styrylchromones and 3\u2010styrylchromones. However, 2\u2010styrylchromones are the most common, being more commonly found in nature and which chemical synthesis is more commonly described. A wide variety of SC has been described in the literature, with different substituents in different positions, the majority of which are distributed on the A\u2010 and\/or B\u2010rings. Over the years, several biological activities have been attributed to SC. This work presents a comprehensive review of the biological activities attributed to SC and their structure\u2010activity relationship, based on a published literature search, since 1989. The following biological activities are thoroughly revised and discussed in this review: antioxidant, antiallergic, antiviral, antibacterial, antifungal, anti\u2010inflammatory, and antitumoral, affinity and selectivity for A<jats:sub>3<\/jats:sub> adenosine receptors, neuroprotective, and <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase inhibition. In general, SC are composed by a promising scaffold with great potential for the development of new drugs.<\/jats:p>","DOI":"10.1155\/2021\/2804521","type":"journal-article","created":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T23:35:09Z","timestamp":1640561709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["[Retracted] Styrylchromones: Biological Activities and Structure\u2010Activity Relationship"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-0708","authenticated-orcid":false,"given":"Mariana","family":"Lucas","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9114-9967","authenticated-orcid":false,"given":"Marisa","family":"Freitas","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M. 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