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Recent studies have highlighted the possible role of interleukins in nonhistaminergic itch. We investigated the role of IL-31 and IL-8 in CTCL, concerning disease severity and associated itch. Serum samples of 27 patients with CTCL (17 MF and 10 SS) and 29 controls (blood donors) were analyzed for interleukin- (IL-) 31 and IL-8; correlations with disease and itch severity were evaluated. IL-31 serum levels were higher in CTCL patients than in controls and higher in SS than in MF. Also, serum IL-31 levels were higher in patients with advanced disease compared to those with early disease, and they correlated positively with lactate dehydrogenase and beta 2-microglobulin levels, as well as with the S\u00e9zary cell count. Itch affected 67% of CTCL patients (MF: 47%; SS: 100%). Serum IL-31 levels were higher in itching patients than in controls and in patients without itching. There was no association between serum IL-8 and disease severity, nor with itching. Serum IL-8 levels correlated positively with peripheral blood leukocyte and neutrophil counts in CTCL patients. Our study suggests a role for IL-31 in CTCL-associated itch, especially in advanced disease and SS, offering a rational target for new therapeutic approaches. Increased serum IL-8 observed in some patients may be related to concomitant infections, and its role in exacerbating itch by recruiting neutrophils and promoting the release of neutrophil proteases deserves further investigation.<\/jats:p>","DOI":"10.1155\/2021\/5582581","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T18:50:05Z","timestamp":1626893405000},"page":"1-12","source":"Crossref","is-referenced-by-count":15,"title":["IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch"],"prefix":"10.1155","volume":"2021","author":[{"given":"Maria","family":"Abreu","sequence":"first","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio do Porto (CHUP), Porto, Portugal"}]},{"given":"Marta","family":"Miranda","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade do Porto (FFUP), Porto, 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