{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T16:29:05Z","timestamp":1750350545208,"version":"3.37.3"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DOCnet","award":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"]}]},{"name":"Norte Portugal Regional Operational Program","award":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NETDIAMOND","award":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"]}]},{"name":"European Structural and Investment Funds","award":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"]}]},{"name":"Lisbon\u2019s Regional Operational Program","award":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000003","POCI-01-0145-FEDER-016385"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2021,3,31]]},"abstract":"<jats:p>Background. Thyroid hormones (TH) are crucial for cardiovascular homeostasis. Recent evidence suggests that acute cardiovascular conditions, particularly acute heart failure (AHF), significantly impair the thyroid axis. Our aim was to evaluate the association of thyroid function with cardiovascular parameters and short- and long-term clinical outcomes in AHF patients. Methods. We performed a single-centre retrospective cohort study including patients hospitalized for AHF between January 2012 and December 2017. We used linear, logistic, and Cox proportional hazard regression models to analyse the association of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) with inpatient cardiovascular parameters, in-hospital mortality, short-term adverse clinical outcomes, and long-term mortality. Two models were used: (1) unadjusted, and (2) adjusted for age and sex. Results. Of the 235 patients included, 59% were female, and the mean age was 77.5 (SD 10.4) years. In the adjusted model, diastolic blood pressure was positively associated with TSH [\u03b2\u2009=\u20092.68 (0.27 to 5.09); <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.030<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>]; left ventricle ejection fraction (LVEF) was negatively associated with FT4 [\u03b2\u2009=\u2009-24.85 (-47.87 to -1.82); <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.035<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>]; and a nonsignificant trend for a positive association was found between 30-day all-cause mortality and FT4 [OR\u2009=\u20093.40 (0.90 to 12.83); <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.071<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>]. Among euthyroid participants, higher FT4 levels were significantly associated with a higher odds of 30-day all-cause death [OR\u2009=\u20094.40 (1.06 to 18.16); <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.041<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>]. Neither TSH nor FT4 levels were relevant predictors of long-term mortality in the adjusted model. Conclusions. Thyroid function in AHF patients is associated with blood pressure and LVEF during hospitalization. FT4 might be useful as a biomarker of short-term adverse outcomes in these patients.<\/jats:p>","DOI":"10.1155\/2021\/6616681","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T18:07:16Z","timestamp":1617214036000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Thyroid Function in Patients Hospitalized for Acute Heart Failure"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4111-3787","authenticated-orcid":true,"given":"Ana Rita","family":"Leite","sequence":"first","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8173-8255","authenticated-orcid":true,"given":"Jo\u00e3o S\u00e9rgio","family":"Neves","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"},{"name":"Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-3751","authenticated-orcid":true,"given":"Marta","family":"Borges-Canha","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"},{"name":"Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"given":"Catarina","family":"Vale","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"given":"Madalena","family":"von Hafe","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3156-3741","authenticated-orcid":true,"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-3596","authenticated-orcid":true,"given":"Adelino","family":"Leite-Moreira","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.045"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0416"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.9052"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2012.08.017"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.10.070"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.891163"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.9.1033"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/981638"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028753"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3586"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020789"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005266"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.42"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2012.10.004"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-019-1055-x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-019-06870-4"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-09-0412"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00225-9"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.10.045"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1089\/105072502760143908"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-008-9126-6"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.08.008"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048124.64204.3F"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.289"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.038"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12084"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2019.01.007"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.10.021"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2015.04.006"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.10.051"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.11.039"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.064"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"35","first-page":"1","article-title":"KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2013","journal-title":"Kidney International Supplements"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S002"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-012-9668-8"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2208"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0087"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.592"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1998.0900"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6614-2-4"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2480"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(84)90203-8"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.23.1.0455"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-022013"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151611.89232.3B"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht456"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7771"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44678"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90462-X"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0375"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.07.052"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03440110095035"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.041"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2021\/6616681.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2021\/6616681.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2021\/6616681.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T18:07:30Z","timestamp":1617214050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ije\/2021\/6616681\/"}},"subtitle":[],"editor":[{"given":"Giuseppe","family":"Reimondo","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2021,3,31]]},"references-count":57,"alternative-id":["6616681","6616681"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6616681","relation":{},"ISSN":["1687-8345","1687-8337"],"issn-type":[{"type":"electronic","value":"1687-8345"},{"type":"print","value":"1687-8337"}],"subject":[],"published":{"date-parts":[[2021,3,31]]}}}