{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:57:45Z","timestamp":1775725065144,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,5,17]]},"abstract":"<jats:p>Corticosteroids are used in a variety of ophthalmological diseases. One challenge faced by ophthalmologists is to deliver corticosteroids to the posterior segment of the eye with efficacy and safety. Sustained-release corticosteroid implants may be the answer to this problem. The 0.19\u2009mg fluocinolone acetonide (FAc) implant (Iluvien\u00ae) releases FAc for 36 months, and it is approved for the treatment of diabetic macular edema (DME) and noninfectious uveitis. We decided to do a systematic review to acknowledge in which other diseases FAc implant is being used off-label. A literature search was performed in the following three electronic databases: PubMed, Scopus, and Web of Science (from January 1st, 2000, to September 20th, 2020), using the following query: (\u201cFluocinolone Acetonide\u201d OR Iluvien\u00ae) AND (\u201ceye\u201d OR \u201cocular\u201d OR \u201cintravitreal).\u201d A total of 11 papers were included, and the use of FAc implant was analyzed in the following diseases: radiation-induced maculopathy (RM); paraneoplastic visual syndromes (melanoma-associated retinopathy (MAR) and cancer-associated retinopathy (CAR)); Sjogren\u2019s syndrome-related keratopathy; retinal vein occlusion (RVO); cystoid macular edema (CME); diabetic retinal neurodegeneration (DRN); and retinitis pigmentosa (RP). FAc implant may be a potential treatment for these diseases; however, the level of scientific evidence of the included studies in this review is limited. Further studies with larger cohorts and longer follow-ups are needed to validate this data.<\/jats:p>","DOI":"10.1155\/2021\/6678364","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T20:50:08Z","timestamp":1621371008000},"page":"1-12","source":"Crossref","is-referenced-by-count":10,"title":["Off-Label Use of 0.19\u2009mg Fluocinolone Acetonide Intravitreal Implant: A Systematic Review"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1780-0699","authenticated-orcid":true,"given":"Fl\u00e1vio","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4718-0910","authenticated-orcid":true,"given":"Manuel S.","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Ophthalmology, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Alameda Professor Hern\u00e2ni Monteiro, Porto 4200-319, Portugal"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/989501"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.01.002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.477"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/17441692.2011.634815"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.03.018"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.09.004"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/nor.0000000000000595"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/icu.0b013e328330ccb9"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-1549(02)00034-2"},{"key":"10","volume-title":"ILUVIEN 190 Micrograms Intravitreal Implant in Applicator","author":"Alimera Sciences Limited","year":"2019"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000000726"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22259"},{"issue":"11","key":"13","first-page":"3569","article-title":"Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device","volume":"41","author":"G. 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