{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:45:29Z","timestamp":1747190729914,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:00:00Z","timestamp":1627689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2021,7,31]]},"abstract":"<jats:p>Primary Sj\u00f6gren syndrome (SS) is a chronic inflammatory systemic autoimmune disease with a high risk of malignancy development, namely, lymphoproliferative neoplasms. Few studies also reported a high risk of solid cancers; however, the coexistence of primary SS and pancreatic cancer has been rarely described. In this paper, we aim to describe a case of a 59-year-old woman who was an active smoker with sicca symptoms and symmetrical polyarthritis and was diagnosed with primary SS two years before the development of metastatic pancreatic adenocarcinoma. Despite institution of chemotherapy, the patient succumbed to the malignancy. Besides that, we explore the link between primary SS and solid cancers including the main predictors of malignancy and the role of primary SS as a paraneoplastic syndrome. Patients with primary SS should be closely monitored for malignancy, not only for hematological cancer, but also for solid tumors. Further research is necessary to understand which are the predictors of cancer proliferation in primary SS patients.<\/jats:p>","DOI":"10.1155\/2021\/9915881","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T23:50:05Z","timestamp":1628034605000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Pancreatic Cancer and Primary Sj\u00f6gren\u2019s Syndrome: A Case Report"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-3162","authenticated-orcid":true,"given":"Daniela","family":"Oliveira","sequence":"first","affiliation":[{"name":"Rheumatology Department, University Hospital Center of S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-2422","authenticated-orcid":true,"given":"Vanessa","family":"Chaves","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, University Hospital Center of S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8806-5471","authenticated-orcid":true,"given":"Jos\u00e9 Carlos","family":"Martins","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, University Hospital Center of S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-2874","authenticated-orcid":true,"given":"Carlos","family":"Vaz","sequence":"additional","affiliation":[{"name":"Rheumatology Department, University Hospital Center of S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Medicine of Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-5465","authenticated-orcid":true,"given":"Miguel","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Rheumatology Department, University Hospital Center of S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Medicine of Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1337-7179","authenticated-orcid":true,"given":"Jorge","family":"Almeida","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, University Hospital Center of S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Medicine of Faculty of Medicine, University of Porto, Porto, Portugal"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep404"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei281"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200402"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0464-5"},{"issue":"10","key":"5","first-page":"912","article-title":"Unusual cancer in primary Sj\u00f6gren syndrome","volume":"60","author":"W.-S. Lai","year":"2014","journal-title":"Canadian Family Physician"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.13927"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239769"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8123"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.02.001"},{"issue":"3","key":"10","first-page":"454","article-title":"Primary Sj\u00f6gren\u2019s syndrome as paraneoplastic disorder: a case report","volume":"30","author":"E. Bartoloni","year":"2012","journal-title":"Clinical and Experimental Rheumatology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/bf02206848"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2016.10.19"},{"issue":"11","key":"13","first-page":"6669","article-title":"Cancer diagnosis in a cohort of patients with Sjogren\u2019s syndrome and rheumatoid arthritis: a single-center experience and review of the literature","volume":"34","author":"S. Boussios","year":"2014","journal-title":"Anticancer Research"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-019-04433-2"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000003540"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(96)90699-4"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(87)90305-9"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000003766"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.13464"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.041186"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604906"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.5152\/ejbh.2019.5128"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key329"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/BF02788358"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22216"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.12.124"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/art.10221"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110754"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082620"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.07.013"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.594096"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0851-2"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.71.2026"}],"container-title":["Case Reports in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2021\/9915881.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2021\/9915881.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2021\/9915881.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T23:50:10Z","timestamp":1628034610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crirh\/2021\/9915881\/"}},"subtitle":[],"editor":[{"given":"James V.","family":"Dunne","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2021,7,31]]},"references-count":33,"alternative-id":["9915881","9915881"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9915881","relation":{},"ISSN":["2090-6897","2090-6889"],"issn-type":[{"type":"electronic","value":"2090-6897"},{"type":"print","value":"2090-6889"}],"subject":[],"published":{"date-parts":[[2021,7,31]]}}}