{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:26:37Z","timestamp":1771845997778,"version":"3.50.1"},"reference-count":181,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>The genus <jats:italic>Papaver<\/jats:italic> is highly esteemed in the pharmacy industry, in the culinary field, and as ornamental plants. These plants are also valued in traditional medicine. Among all <jats:italic>Papaver<\/jats:italic> species, <jats:italic>Papaver somniferum<\/jats:italic> L. (opium poppy) is the most important species in supplying phytochemicals for the formulation of drugs, mainly alkaloids like morphine, codeine, rhoeadine, thebaine, and papaverine. In addition, <jats:italic>Papaver<\/jats:italic> plants present other types of phytochemicals, which altogether are responsible for its biological activities. Therefore, this review covers the phytochemical composition of <jats:italic>Papave<\/jats:italic>r plants, including alkaloids, phenolic compounds, and essential oils. The traditional uses are reviewed along with their pharmacological activities. Moreover, safety aspects are reported to provide a deep overview of the pharmacology potential of this genus. An updated search was carried out in databases such as Google Scholar, ScienceDirect, and PubMed to retrieve the information. Overall, this genus is a rich source of alkaloids of different types and also contains interesting phenolic compounds, such as anthocyanins, flavonols, and the characteristic indole derivatives nudicaulins. Among other pharmacological properties, numerous preclinical studies have been published about the analgesic, anticancer, antimicrobial, antioxidant, and antidiabetic activities of <jats:italic>Papaver<\/jats:italic> plants. Although it highlights the significant impact of this genus for the treatment of a variety of diseases and conditions, as a future prospect, characterization works accompanying preclinical studies are required along with clinical and toxicology studies to establish a correlation between the scientific and traditional knowledge.<\/jats:p>","DOI":"10.1155\/2022\/2041769","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:35:11Z","timestamp":1643934911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["<i>Papaver<\/i> Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-5000","authenticated-orcid":false,"given":"Monica","family":"Butnariu","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2090-3288","authenticated-orcid":false,"given":"Cristina","family":"Quispe","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-7920","authenticated-orcid":false,"given":"Jes\u00fas","family":"Herrera-Bravo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4402-1693","authenticated-orcid":false,"given":"Marius","family":"Pentea","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1141-2102","authenticated-orcid":false,"given":"Ioan","family":"Sarac","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-8042","authenticated-orcid":false,"given":"Aylin Seylam","family":"K\u00fc\u015f\u00fcmler","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1810-8154","authenticated-orcid":false,"given":"Beraat","family":"\u00d6z\u00e7elik","sequence":"additional","affiliation":[]},{"given":"Sakshi","family":"Painuli","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-5169","authenticated-orcid":false,"given":"Prabhakar","family":"Semwal","sequence":"additional","affiliation":[]},{"given":"Muhammad","family":"Imran","sequence":"additional","affiliation":[]},{"given":"Tanweer Aslam","family":"Gondal","sequence":"additional","affiliation":[]},{"given":"Simin","family":"Emamzadeh-Yazdi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-717X","authenticated-orcid":false,"given":"Natallia","family":"Lapava","sequence":"additional","affiliation":[]},{"given":"Zubaida","family":"Yousaf","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-6497","authenticated-orcid":false,"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[]},{"given":"Ali Hussein","family":"Eid","sequence":"additional","affiliation":[]},{"given":"Yusra","family":"Al-Dhaheri","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-0830","authenticated-orcid":false,"given":"Hafiz Ansar Rasul","family":"Suleria","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-0088","authenticated-orcid":false,"given":"Mar\u00eda","family":"del Mar Contreras","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-4586","authenticated-orcid":false,"given":"William C.","family":"Cho","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-018-9563-3"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020437"},{"key":"e_1_2_12_3_2","volume-title":"Mabberley\u2019s Plant-Book","author":"Mabberley D. J.","year":"2008"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40415-020-00629-0"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/rs10121886"},{"key":"e_1_2_12_6_2","unstructured":"United Nations Economic and Social Council 2021 https:\/\/undocs.org\/pdf?symbol=en\/E\/CN.7\/2021\/5."},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2020.101793"},{"key":"e_1_2_12_8_2","unstructured":"FAOSTAT 2021 https:\/\/www.fao.org\/faostat\/es\/#data\/QC."},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.egg.2020.100058"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1614\/WS-07-077.1"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-017-0966-8"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.15553\/c2019v741a7"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01614"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394290-6.00011-2"},{"key":"e_1_2_12_15_2","volume-title":"Morphine","author":"Murphy P. B.","year":"2021"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2013.878936"},{"key":"e_1_2_12_17_2","unstructured":"United Nations Office on Drugs and Crime 2020 https:\/\/www.unodc.org\/unodc\/en\/data-and-analysis\/bulletin\/bulletin_1953-01-01_3_page005.html."},{"key":"e_1_2_12_18_2","unstructured":"EFSA EFSA Opium alkaloids in poppy seeds: 2019 https:\/\/www.efsa.europa.eu\/en\/press\/news\/180516."},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.17660\/ActaHortic.2014.1036.3"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2010.520542"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1097192"},{"key":"e_1_2_12_22_2","volume-title":"Ethnopharmacology","author":"Calixto J. B."},{"key":"e_1_2_12_23_2","first-page":"7","article-title":"Ethnobotanical survey of medicinal plants used traditionally in two villages of Hamedan, Iran","volume":"1","author":"Naghibi F.","year":"2014","journal-title":"Research Journal of Pharmacognosy"},{"key":"e_1_2_12_24_2","first-page":"31","article-title":"Ethnomedicinal plants of Farouj district, north khorasan province, Iran","volume":"1","author":"Farouji A. E.","year":"2016","journal-title":"Journal of Herbal Drugs (An International Journal on Medicinal Herbs)"},{"key":"e_1_2_12_25_2","doi-asserted-by":"crossref","unstructured":"AltundagaE.andOzturkbM. Ethnomedicinal studies on the plant resources of east Anatolia Turkey 2011 19 Procedia Social and Behavioral Sciences: The 2nd International Geography Symposium GEOMED2010 East Anatolia; Turkey 756\u2013777.","DOI":"10.1016\/j.sbspro.2011.05.195"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.5897\/JMPR10.028"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/09735070.2013.11886446"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.12.004"},{"key":"e_1_2_12_29_2","first-page":"101","article-title":"Traditional ethnobotanical knowledge about medicinal plants used for external therapies in Alasehir, Turkey","volume":"1","author":"Ugulu I.","year":"2011","journal-title":"International Journal of Medicinal and Aromatic Plants"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.37358\/RC.17.2.5465"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.11.045"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10722-012-9859-x"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00207-X"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.04.028"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.11.002"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.10.005"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(14)60257-1"},{"key":"e_1_2_12_38_2","first-page":"153","article-title":"Ethnomedicinal uses of plants for the treatment of nervous disorders at the herbal markets of Bojnord, North Khorasan Province, Iran","volume":"2","author":"Nadaf M.","year":"2019","journal-title":"Avicenna journal of phytomedicine"},{"key":"e_1_2_12_39_2","first-page":"263","article-title":"Ethnomedical plants used by Bhil tribe of Bibdod, Madhya Pradesh","volume":"5","author":"Jadnav D.","year":"2006","journal-title":"Indian Journal of Traditional Knowledge"},{"key":"e_1_2_12_40_2","first-page":"278","article-title":"Ethnomedicinal practices of Kashmir Valley: a review","volume":"7","author":"Dar P. A.","year":"2018","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/fqsafe\/fyx013"},{"key":"e_1_2_12_42_2","first-page":"8","article-title":"Ethnomedicinal applications of spices and condiments in Nandurbar District (Maharashtra)","volume":"2","author":"Tayade S. K.","year":"2010","journal-title":"Journal of Ecobiotechnology"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-10-16"},{"key":"e_1_2_12_44_2","first-page":"2049","article-title":"Ethnomedicinal survey of plants of Valley Alladand Dehri, Tehsil Batkhela, District Malakand, Pakistan","volume":"3","author":"Alamgeer T. A.","year":"2013","journal-title":"International Journal of Basic Medical Sciences and Pharmacy"},{"key":"e_1_2_12_45_2","first-page":"208","article-title":"Ethnomedicinal and traditional knowledge of phanerogames of Tehsil Munda, district Lower Dir, Khyber Pakhtunkhwa, Pakistan","volume":"4","author":"Irfan M.","year":"2018","journal-title":"International Journal of Biosciences"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.09.048"},{"key":"e_1_2_12_47_2","first-page":"673","article-title":"Analyss of ethnomedical practices for treating skin diseases in communities on Jeju Island (Korea)","volume":"13","author":"Kim H.","year":"2014","journal-title":"Indian Journal of Traditional Knowledge"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2019.07.042"},{"key":"e_1_2_12_49_2","first-page":"217","article-title":"6- Phytochemical and biological research of Papaver pharmaceutical resources","author":"Hao D. C.","year":"2015","journal-title":"Medicinal Plants, Chemisty, Biology and Omics"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jplph.2018.01.007"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.04.015"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-020-02663-9"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac200274040557"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/np0496643"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-007-0739-0"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c01681"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1079\/IVP2001287"},{"key":"e_1_2_12_58_2","first-page":"644","article-title":"Molecular characterisation of the genus Papaver section Oxytona using ISSR markers","volume":"37","author":"G\u00fcrk\u00f6k T.","year":"2013","journal-title":"Turkish Journal of Botany"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.12.079"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-962072"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)85017-N"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5178729"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2018.08.020"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2017.1340964"},{"key":"e_1_2_12_65_2","volume-title":"Department of Pharmacognosy Phytochemical and pharmacological studies on some Papaver species in Turkey","author":"Bayazeid O.","year":"2017"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25112636"},{"key":"e_1_2_12_67_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880200701538948"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1080\/10575630008041232"},{"key":"e_1_2_12_69_2","unstructured":"HMDB 2012 https:\/\/hmdb.ca\/metabolites\/HMDB0030169."},{"key":"e_1_2_12_70_2","doi-asserted-by":"publisher","DOI":"10.5897\/JMPR10.121"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00383-4"},{"key":"e_1_2_12_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02095584"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.3390\/plants5020028"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2013.04.011"},{"key":"e_1_2_12_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2005.11.002"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.02.023"},{"key":"e_1_2_12_77_2","doi-asserted-by":"publisher","DOI":"10.5578\/fmbd.67616"},{"key":"e_1_2_12_78_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0580869"},{"key":"e_1_2_12_79_2","first-page":"545","article-title":"Essential oil composition of Papaver rhoeas L. (corn poppy) (Papaveraceae) from Turkey","volume":"42","author":"Dogan G.","year":"2014","journal-title":"Hacettepe Journal of Biology and Chemistry"},{"key":"e_1_2_12_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.08.032"},{"key":"e_1_2_12_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2012.04.018"},{"key":"e_1_2_12_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.05.006"},{"key":"e_1_2_12_83_2","first-page":"1895","article-title":"Cytotoxic and of Papaver pavoninum Fisch & Mey","volume":"47","author":"Ibrar M.","year":"2015","journal-title":"Pakistan Journal of Botany"},{"key":"e_1_2_12_84_2","first-page":"141","article-title":"Effects of Papaver rhoeas extract on the tolerance development to analgesic effects of morphine in mice","volume":"7","author":"Shams J.","year":"2008","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2019.01.007"},{"key":"e_1_2_12_86_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123357"},{"key":"e_1_2_12_87_2","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v13i3.3"},{"key":"e_1_2_12_88_2","doi-asserted-by":"publisher","DOI":"10.18596\/jotcsa.43273"},{"key":"e_1_2_12_89_2","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2011_05_386"},{"key":"e_1_2_12_90_2","first-page":"4","article-title":"Sublethal UVB induces DNA lesions and pro-apoptotic gene transcription in human keratinocytes: attenuation by a mixture of plant extracts","volume":"1","author":"Ennamany R.","year":"2013","journal-title":"Journal of Preventive Medicine"},{"key":"e_1_2_12_91_2","first-page":"295","article-title":"Cytotoxicity and antioxidant activity of 23 plant species of Leguminosae family","volume":"11","author":"Khalighi-Sigaroodi F.","year":"2012","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_12_92_2","first-page":"101","article-title":"Antioxidant, antibacterial activities and general toxicity of Alnus glutinosa, Fraxinus excelsior and Papaver rhoeas","volume":"4","author":"Middleton P.","year":"2005","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_12_93_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm501180v"},{"key":"e_1_2_12_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-019-02837-x"},{"key":"e_1_2_12_95_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00864"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-018-3464-z"},{"key":"e_1_2_12_97_2","first-page":"1432","article-title":"Synergistic anticancer effect of paclitaxel and noscapine on human prostate cancer cell lines","volume":"16","author":"Rabzia A.","year":"2017","journal-title":"Iran Journal of Pharmaceutical Research"},{"key":"e_1_2_12_98_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2017.1344097"},{"key":"e_1_2_12_99_2","first-page":"606","article-title":"Knock-down of cadherin 17 inhibits proliferation and promote apoptosis in noscapine-resistant human SW480 colon cancer cells","volume":"33","author":"Han Z.","year":"2017","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep37062"},{"key":"e_1_2_12_101_2","first-page":"112","article-title":"Papaverine selectively inhibits human prostate cancer cell (PC-3) growth by inducing mitochondrial mediated apoptosis, cell cycle arrest and downregulation of NF-\u03baB\/PI3K\/Akt signalling pathway","volume":"22","author":"Huang H.","year":"2017","journal-title":"Official journal of the Balkan Union of Oncology"},{"key":"e_1_2_12_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.109740"},{"key":"e_1_2_12_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.08.012"},{"key":"e_1_2_12_104_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190811846"},{"key":"e_1_2_12_105_2","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2015.1045656"},{"key":"e_1_2_12_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0205-x"},{"key":"e_1_2_12_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0321-7"},{"key":"e_1_2_12_108_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808945115"},{"key":"e_1_2_12_109_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216358"},{"key":"e_1_2_12_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.08.006"},{"key":"e_1_2_12_111_2","first-page":"4131","article-title":"Antimicrobial activity and phytochemical analysis of selected Indian spices","volume":"8","author":"Kumaravel S.","year":"2014","journal-title":"Journal of Pure and Applied Microbiology"},{"key":"e_1_2_12_112_2","first-page":"433","article-title":"In vitro fungicidal activity of spices against root infecting fungi","volume":"40","author":"Dawar S.","year":"2008","journal-title":"Pakistan Journal of Botany"},{"key":"e_1_2_12_113_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880200802392468"},{"key":"e_1_2_12_114_2","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2012-1-204"},{"key":"e_1_2_12_115_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-111631"},{"key":"e_1_2_12_116_2","first-page":"97","article-title":"Antioxidant, antimicrobial actiyity and heavy metals content in pollen of Papaver somniferum L","volume":"17","author":"Ka\u010d\u00e1niov\u00e1 M.","year":"2010","journal-title":"Ecological Chemistry and Engineering A"},{"key":"e_1_2_12_117_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880200390501488"},{"key":"e_1_2_12_118_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199911)13:7<616::AID-PTR475>3.0.CO;2-V"},{"key":"e_1_2_12_119_2","first-page":"119","article-title":"Antioxidant activity and phenolic contents of ajwain, mustard, fenugreek and poppy seed","volume":"7","author":"Ishtiaque S.","year":"2014","journal-title":"Recent Innovations in Chemical Engineering"},{"key":"e_1_2_12_120_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201700389"},{"key":"e_1_2_12_121_2","article-title":"Free radical scavenging capacity of Papaver somniferum L. and determination of pharmacologically active alkaloids using capillary electrophoresis","volume":"1","author":"Baros S.","year":"2012","journal-title":"Journal of Microbiology, Biotechnology and Food Sciences"},{"key":"e_1_2_12_122_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-018-1839-9"},{"key":"e_1_2_12_123_2","first-page":"34","article-title":"Oxidant\/antioxidant equilibrium in rats supplemented with diesel fuel or with opium poppy (Papaver somniferum L.) seed oil biodiesel","volume":"164","author":"Aksoy L.","year":"2013","journal-title":"Revue de M\u00e9decine V\u00e9t\u00e9rinaire"},{"key":"e_1_2_12_124_2","doi-asserted-by":"publisher","DOI":"10.18782\/2320-7051.2251"},{"key":"e_1_2_12_125_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2014.0050"},{"key":"e_1_2_12_126_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/923142"},{"key":"e_1_2_12_127_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700176"},{"key":"e_1_2_12_128_2","doi-asserted-by":"publisher","DOI":"10.3136\/fstr.15.59"},{"key":"e_1_2_12_129_2","first-page":"83","article-title":"Screening of antioxidant activity and phenolic content of 24 medicinal plant extracts","volume":"16","author":"Souri E.","year":"2008","journal-title":"DARU Journal of Pharmaceutical Sciences"},{"key":"e_1_2_12_130_2","first-page":"55","article-title":"Antioxidative activity of sixty plants from Iran","volume":"3","author":"Souri E.","year":"2004","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_12_131_2","doi-asserted-by":"publisher","DOI":"10.1080\/09637480310001642501"},{"key":"e_1_2_12_132_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2006.00125.x"},{"key":"e_1_2_12_133_2","article-title":"An ethno-medicinal study of medicinal plants used for the treatment of diabetes","volume":"5","author":"Baharvand-Ahmadi B.","year":"2016","journal-title":"Journal of Nephropathology"},{"key":"e_1_2_12_134_2","doi-asserted-by":"publisher","DOI":"10.21448\/ijsm.430703"},{"key":"e_1_2_12_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2019.01.001"},{"key":"e_1_2_12_136_2","first-page":"317","article-title":"Medicinal plants used for the treatment of diabetes in Turkey","volume":"39","author":"Sarikaya S. \u00d6.","year":"2010","journal-title":"Ankara \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Dergisi"},{"key":"e_1_2_12_137_2","doi-asserted-by":"publisher","DOI":"10.9734\/IJBCRR\/2016\/23301"},{"key":"e_1_2_12_138_2","first-page":"258","article-title":"Effect of opium on glucose metabolism and lipid profiles in rats with streptozotocin-induced diabetes","volume":"60","author":"Sadeghian S.","year":"2009","journal-title":"Endokrynologia Polska"},{"key":"e_1_2_12_139_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12522-010-0059-0"},{"key":"e_1_2_12_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2013.06.010"},{"key":"e_1_2_12_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.recli.2016.11.002"},{"key":"e_1_2_12_142_2","doi-asserted-by":"publisher","DOI":"10.9783\/9780812290882"},{"key":"e_1_2_12_143_2","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2013.1016.1021"},{"key":"e_1_2_12_144_2","first-page":"21","article-title":"The effect of Papaver rhoeas distillate on learning, memory, corticosterone and anorexia in little laboratory mice under inescapable tension","volume":"23","author":"Mirzaei P.","year":"2013","journal-title":"Medical Science Journal of Islamic Azad Univesity-Tehran Medical Branch"},{"key":"e_1_2_12_145_2","doi-asserted-by":"publisher","DOI":"10.15412\/J.BCN.03070304"},{"key":"e_1_2_12_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(03)00174-0"},{"key":"e_1_2_12_147_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2497-5"},{"key":"e_1_2_12_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00048-3"},{"key":"e_1_2_12_149_2","unstructured":"WHO 2019 https:\/\/link.springer.com\/article\/10.1007\/s11060-010-0321-7."},{"key":"e_1_2_12_150_2","doi-asserted-by":"publisher","DOI":"10.1177\/2049463712438493"},{"key":"e_1_2_12_151_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0929"},{"key":"e_1_2_12_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00090-0"},{"key":"e_1_2_12_153_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200109000-00029"},{"key":"e_1_2_12_154_2","doi-asserted-by":"publisher","DOI":"10.1080\/23809000.2016.1131595"},{"key":"e_1_2_12_155_2","doi-asserted-by":"crossref","DOI":"10.3402\/ecrj.v3.30629","article-title":"Opioids: an unexplored option for treatment of dyspnea in IPF","volume":"3","author":"Kohberg C.","year":"2016","journal-title":"European Clinical Respiratory Journal"},{"key":"e_1_2_12_156_2","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20120031"},{"key":"e_1_2_12_157_2","unstructured":"EFSA 2018 https:\/\/www.efsa.europa.eu\/en\/press\/news\/180516."},{"key":"e_1_2_12_158_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30430-1"},{"key":"e_1_2_12_159_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1054423"},{"key":"e_1_2_12_160_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12420"},{"key":"e_1_2_12_161_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090457"},{"key":"e_1_2_12_162_2","doi-asserted-by":"publisher","DOI":"10.1177\/0009922815594586"},{"key":"e_1_2_12_163_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.157"},{"key":"e_1_2_12_164_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b06655"},{"key":"e_1_2_12_165_2","doi-asserted-by":"publisher","DOI":"10.1111\/1556-4029.13562"},{"key":"e_1_2_12_166_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-019-0113-5"},{"key":"e_1_2_12_167_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00456.x"},{"key":"e_1_2_12_168_2","doi-asserted-by":"publisher","DOI":"10.1159\/000092557"},{"key":"e_1_2_12_169_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/321360"},{"key":"e_1_2_12_170_2","first-page":"1189","article-title":"Hepatotoxicity associated with the ingestion of Papaver rhoease","volume":"64","author":"Gonullu H.","year":"2014","journal-title":"Journal of Pakistan Medical Association"},{"key":"e_1_2_12_171_2","first-page":"717","article-title":"Antigenotoxic capacity of Papaver rhoeas L. extract","volume":"6","author":"Gateva S.","year":"2014","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_12_172_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10745-010-9318-2"},{"key":"e_1_2_12_173_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00100-9"},{"key":"e_1_2_12_174_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950315)75:6<1245::AID-CNCR2820750606>3.0.CO;2-U"},{"key":"e_1_2_12_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2020.01.004"},{"key":"e_1_2_12_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2012.01.026"},{"key":"e_1_2_12_177_2","first-page":"101","article-title":"Medicinal aspects of opium as described in Avicenna's canon of medicine","volume":"11","author":"Heydari M.","year":"2013","journal-title":"Acta Medico-Historica Adriatica"},{"key":"e_1_2_12_178_2","article-title":"Cytotoxic activity of alkaloids from Papaver rhoeas growing in Lebanon","volume":"11","author":"Hijazi M. A.","year":"2017","journal-title":"Records of Natural Products"},{"key":"e_1_2_12_179_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8935085"},{"key":"e_1_2_12_180_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103192"},{"key":"e_1_2_12_181_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201701402"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/2041769.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/2041769.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/2041769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:10:08Z","timestamp":1748913008000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/2041769"}},"subtitle":[],"editor":[{"given":"Tarique","family":"Hussain","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":181,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/2041769"],"URL":"https:\/\/doi.org\/10.1155\/2022\/2041769","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2041769"}}