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The epidemiology of this virus is still poorly understood despite its relevance for domestic and wild rabbits. During a longitudinal capture-mark-recapture (CMR) study of wild Iberian rabbits, O. c. algirus, in a semiextensive breeding enclosure, an outbreak of RHDV GI.2 took place in January-February 2022, allowing us to estimate key epidemiological parameters of a natural outbreak. From April 2021 to July 2022, 340 rabbits were captured 466 times and individually identified, and some were vaccinated against myxoma virus (MYXV) and\/or RHDV GI.2. Sera were collected and tested for IgG specific for MYXV and RHDV GI.2, and data were analyzed using multievent CMR models. During six weeks in January-February 2022, an estimated 81.0% (CI95 77.1\u201384.3%) of the population died. Intensive aboveground searches could recover 189 carcasses (50.5% of the estimated mortality, CI95 41.8\u201363.4%), with RHDV GI.2 detected in 6\/7 tested. Apparent RHDV GI.2 seroprevalence rose from 15.4% (CI95 8.0\u201327.5%) in January 2022 to 87.9% (CI95 72.7\u201395.2%) in February 2022. The apparent mortality of RHDV GI.2-seropositive rabbits during the outbreak was estimated as null, while for seronegative rabbits, it was 76.0% (CI95 53.8\u201390.3%). Among the seronegative rabbits, mortality was higher in unvaccinated (100%) than in recently vaccinated (60.0\u2009\u00b1\u200916.6%) and in females (100%) than in males (52.0\u2009\u00b1\u200917.1%). Infected carcasses in the burrows might explain the medium-term disease persistence in the population following the outbreak. Rabbits with antibodies at the cutoff for seropositivity were fully protected from fatal infection. Females had a higher fatality rate than males, underscoring the impact of RHDV GI.2 on the population dynamics of this endangered species.<\/jats:p>","DOI":"10.1155\/2023\/3451338","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T23:05:34Z","timestamp":1687215934000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["High Mortality of Wild European Rabbits during a Natural Outbreak of Rabbit Haemorrhagic Disease GI.2 Revealed by a Capture-Mark-Recapture Study"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-9353","authenticated-orcid":true,"given":"Sa\u00fal","family":"Jim\u00e9nez-Ruiz","sequence":"first","affiliation":[{"name":"Research Centre in Biodiversity and Genetic Resources (CIBIO), Associated Laboratory (InBIO), Campus de Vair\u00e3o, University of Porto, Vair\u00e3o 4485-661, Portugal"},{"name":"Program in Genomics, Biodiversity and Land Planning (BIOPOLIS), Campus de Vair\u00e3o, Vair\u00e3o 4485-661, Portugal"},{"name":"Animal Health and Zoonoses Research Group (GISAZ), Competitive Research Unit on Zoonoses and Emerging Diseases (ENZOEM), University of Cordoba, Cordoba 14014, Spain"}]},{"given":"Marta","family":"Rafael","sequence":"additional","affiliation":[{"name":"Research Centre in Biodiversity and Genetic Resources (CIBIO), Associated Laboratory (InBIO), Campus de Vair\u00e3o, University of Porto, Vair\u00e3o 4485-661, Portugal"},{"name":"Program in Genomics, Biodiversity and Land Planning (BIOPOLIS), Campus de Vair\u00e3o, Vair\u00e3o 4485-661, Portugal"}]},{"given":"Joana","family":"Coelho","sequence":"additional","affiliation":[{"name":"Research Centre in Biodiversity and Genetic Resources (CIBIO), Associated Laboratory (InBIO), Campus de Vair\u00e3o, University of Porto, Vair\u00e3o 4485-661, Portugal"},{"name":"Interdisciplinary Research Centre in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisbon 1300-477, Portugal"}]},{"given":"Henrique","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Research Centre in Biodiversity and Genetic Resources (CIBIO), Associated Laboratory (InBIO), Campus de Vair\u00e3o, University of Porto, Vair\u00e3o 4485-661, Portugal"},{"name":"Interdisciplinary Research Centre in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisbon 1300-477, Portugal"}]},{"given":"Manuel","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Noudar Nature Park, Empresa de Desenvolvimento e Infra-Estruturas do Alqueva (EDIA), Barrancos 7230-031, Portugal"}]},{"given":"Paulo C\u00e9lio","family":"Alves","sequence":"additional","affiliation":[{"name":"Research Centre in Biodiversity and Genetic Resources (CIBIO), Associated Laboratory (InBIO), Campus de Vair\u00e3o, University of Porto, Vair\u00e3o 4485-661, Portugal"},{"name":"Program in Genomics, Biodiversity and Land Planning (BIOPOLIS), Campus de Vair\u00e3o, Vair\u00e3o 4485-661, Portugal"},{"name":"Department of Biology, Faculty of Sciences, University of Porto, Porto 4099-002, Portugal"},{"name":"EBM, M\u00e9rtola Biological Station, Pra\u00e7a Lu\u00eds de Cam\u00f5es, M\u00e9rtola 7750-329, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1676-107X","authenticated-orcid":true,"given":"Nuno","family":"Santos","sequence":"additional","affiliation":[{"name":"Research Centre in Biodiversity and Genetic Resources (CIBIO), Associated Laboratory (InBIO), Campus de Vair\u00e3o, University of Porto, Vair\u00e3o 4485-661, Portugal"},{"name":"Program in Genomics, Biodiversity and Land Planning (BIOPOLIS), Campus de Vair\u00e3o, Vair\u00e3o 4485-661, Portugal"},{"name":"EBM, M\u00e9rtola Biological Station, Pra\u00e7a Lu\u00eds de Cam\u00f5es, M\u00e9rtola 7750-329, Portugal"}]}],"member":"311","reference":[{"key":"1","volume-title":"Ecology: The Experimental Analysis of Distribution and Abundance","author":"C. 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